The interaction of mefloquine hydrochloride with cell membrane models at the air-water interface is modulated by the monolayer lipid composition

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dc.contributor.authorGoto, Thiago Eichi [UNIFESP]
dc.contributor.authorCaseli, Luciano [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:37:53Z
dc.date.available2016-01-24T14:37:53Z
dc.date.issued2014-10-01
dc.description.abstractThe antiparasitic properties of antiparasitic drugs are believed to be associated with their interactions with the protozoan membrane, encouraging research on the identification of membrane sites capable of drug binding. in this study, we investigated the interaction of mefloquine hydrochloride, known to be effective against malaria, with cell membrane models represented by Langmuir monolayers of selected lipids. It is shown that even small amounts of the drug affect the surface pressure-area isotherms as well as surface vibrational spectra of some lipid monolayers, which points to a significant interaction. the effects on the latter depend on the electrical charge of the monolayer-forming molecules, with the drug activity being particularly distinctive for negatively charged lipids. Therefore, the lipid composition of the monolayer modulates the interaction with the lipophilic drug, which may have important implications in understanding how the drug acts on specific sites of the protozoan membrane. (C) 2014 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Inst Environm Chem & Pharmaceut Sci, Diadema, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Inst Environm Chem & Pharmaceut Sci, Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 2013/10213-1
dc.description.sponsorshipIDCNPq: 470890/2012-6
dc.format.extent24-30
dc.identifierhttp://dx.doi.org/10.1016/j.jcis.2014.05.050
dc.identifier.citationJournal of Colloid and Interface Science. San Diego: Academic Press Inc Elsevier Science, v. 431, p. 24-30, 2014.
dc.identifier.doi10.1016/j.jcis.2014.05.050
dc.identifier.issn0021-9797
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38235
dc.identifier.wosWOS:000340688900004
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Colloid and Interface Science
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectMefloquine hydrochlorideen
dc.subjectMalariaen
dc.subjectLangmuir monolayersen
dc.subjectDPPCen
dc.subjectDPPGen
dc.subjectDODABen
dc.subjectStearic aciden
dc.subjectPM-IRRASen
dc.subjectAntiparasitic drugen
dc.titleThe interaction of mefloquine hydrochloride with cell membrane models at the air-water interface is modulated by the monolayer lipid compositionen
dc.typeinfo:eu-repo/semantics/article
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