The impact of pulse duration and burn grade on size of retinal photocoagulation lesion: implications for pattern density

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dc.contributor.authorPalanker, Daniel
dc.contributor.authorLavinsky, Daniel [UNIFESP]
dc.contributor.authorBlumenkranz, Mark Scott
dc.contributor.authorMarcellino, George
dc.contributor.institutionStanford Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionOptiMedica Corp
dc.date.accessioned2018-06-18T11:35:37Z
dc.date.available2018-06-18T11:35:37Z
dc.date.issued2011-09-01
dc.description.abstractPurpose: Shorter pulses used in pattern scanning photocoagulation (10-20 milliseconds [ms]) tend to produce lighter and smaller lesions than the Early Treatment Diabetic Retinopathy Study standard 100-ms exposures. Smaller lesions result in fewer complications but may potentially reduce clinical efficacy. It is worthwhile to reevaluate existing standards for the number and size of lesions needed.Methods: The width of the coagulated zone in patients undergoing retinal photocoagulation was measured using optical coherence tomography. Lesions of moderate, light, and barely visible clinical grades were compared for 100, 200, and 400 mu m spot sizes and pulse durations of 20 ms and 100 ms.Results: To maintain the same total area as in 1,000 standard burns (100 ms, moderate) with a 400-mu m beam, a larger number of 20-ms lesions are required: 1,464, 1,979, and 3,520 for moderate, light, and barely visible grades, respectively. Because of stronger relative effect of heat diffusion with a smaller beam, with 200 mu m this ratio increases: 1,932, 2,783, and 5,017 lesions of 20 ms with moderate, light, and barely visible grades correspond to the area of 1,000 standard burns.Conclusion: A simple formula is derived for calculation of the required spot spacing in the laser pattern for panretinal photocoagulation with various laser parameters to maintain the same total coagulated area. RETINA 31: 1664-1669, 2011en
dc.description.affiliationStanford Univ, Hansen Expt Phys Lab, Stanford, CA 94305 USA
dc.description.affiliationStanford Univ, Dept Ophthalmol, Stanford, CA 94305 USA
dc.description.affiliationUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.affiliationOptiMedica Corp, Santa Clara, CA USA
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Ophthalmol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAlcon Research Institute
dc.description.sponsorshipHorngren Foundation
dc.description.sponsorshipMiller Family Foundation
dc.description.sponsorshipAngelos and Penelope Dellaporta Research Fund
dc.format.extent1664-1669
dc.identifierhttp://dx.doi.org/10.1097/IAE.0b013e3182115679
dc.identifier.citationRetina-the Journal Of Retinal And Vitreous Diseases. Philadelphia: Lippincott Williams & Wilkins, v. 31, n. 8, p. 1664-1669, 2011.
dc.identifier.doi10.1097/IAE.0b013e3182115679
dc.identifier.issn0275-004X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/45220
dc.identifier.wosWOS:000294456100027
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofRetina-the Journal Of Retinal And Vitreous Diseases
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectlaseren
dc.subjectphotocoagulationen
dc.subjectdiabetic retinopathyen
dc.subjectpanretinal photocoagulationen
dc.subjectmacular griden
dc.titleThe impact of pulse duration and burn grade on size of retinal photocoagulation lesion: implications for pattern densityen
dc.typeinfo:eu-repo/semantics/article
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