Acute myeloid leukemia in elderly patients: experience of a single center

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dc.contributor.authorRodrigues, Celso Arrais [UNIFESP]
dc.contributor.authorChauffaille, Maria de Lourdes Lopes Ferrari [UNIFESP]
dc.contributor.authorPelloso, L.a.f. [UNIFESP]
dc.contributor.authorGhaname, F.s. [UNIFESP]
dc.contributor.authorKerbauy, Daniela Márcia Bahia [UNIFESP]
dc.contributor.authorCampos, M.g.v. [UNIFESP]
dc.contributor.authorYamamoto, Mihoko [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:30:03Z
dc.date.available2015-06-14T13:30:03Z
dc.date.issued2003-06-01
dc.description.abstractAcute myeloid leukemia (AML) is a disease predominantly of older adults. Treatment of AML in the elderly is complicated not only by comorbidities but also by the high prevalence of poor prognosis markers. Thirty-one consecutive unselected patients with AML older than 60 years (representing 33% of all AML cases diagnosed at our institution during the same period) were followed over a period of 5 years (1997-2002). A high incidence of AML with multilineage dysplasia (45%) and no favorable cytogenetic abnormalities but 62% intermediate and 38% unfavorable karyotypes were found. Sixteen patients (52%) were selected for induction of intensive cytotoxic treatment and complete remission was achieved only by some of these intensively treated patients (7 of 16). Of these, 3 remained alive without disease (median: 11 months), 1 patient died shortly after complete remission, and 3 patients relapsed and died from refractory disease. Only 1 patient that was refractory to intensive cytotoxic treatment remained alive with disease under supportive care. Fifteen patients (48%) were managed with palliative/supportive care: 7 received palliative treatment and supportive care, 8 received supportive care only, and 4 patients remained alive with disease under supportive care (median: 9 months). Mortality rate was 74% and overall survival at two years was 12%. To the best of our knowledge, there is no previous report regarding elderly patients with AML in Brazilian subsets. The present data are similar to previously reported studies showing that elderly AML patients are not only older but also biologically distinct from younger AML patients, particularly in terms of the high incidence of poor prognostic karyotypes and resistance to therapy.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de Hematologia e Hemoterapia
dc.description.affiliationUnifespUNIFESP, EPM, Disciplina de Hematologia e Hemoterapia
dc.description.sourceSciELO
dc.format.extent703-708
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2003000600004
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 36, n. 6, p. 703-708, 2003.
dc.identifier.doi10.1590/S0100-879X2003000600004
dc.identifier.fileS0100-879X2003000600004.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2003000600004
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/1759
dc.identifier.wosWOS:000183866400004
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAcute myeloid leukemiaen
dc.subjectElderly patientsen
dc.subjectG-banding karyotypeen
dc.subjectInduction therapyen
dc.subjectOverall survivalen
dc.titleAcute myeloid leukemia in elderly patients: experience of a single centeren
dc.typeinfo:eu-repo/semantics/article
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