Urinary alpha-GST and pi-GST for prediction of dialysis requirement or in-hospital death in established acute kidney injury

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dc.contributor.authorSeabra, Victor F. [UNIFESP]
dc.contributor.authorPerianayagam, Mary C.
dc.contributor.authorTighiouart, Hocine
dc.contributor.authorLiangos, Orfeas
dc.contributor.authorSantos, Oscar F. P. dos [UNIFESP]
dc.contributor.authorJaber, Bertrand L.
dc.contributor.institutionSt Elizabeths Med Ctr
dc.contributor.institutionTufts Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionTufts Med Ctr
dc.contributor.institutionKlinikum Coburg
dc.date.accessioned2016-01-24T14:17:33Z
dc.date.available2016-01-24T14:17:33Z
dc.date.issued2011-12-01
dc.description.abstractContext: Urinary alpha-glutathione S-transferase (alpha-GST) and pi-glutathione S-transferase (pi-GST) are promising proximal and distal tubular leakage markers for early detection of acute kidney injury (AKI).Objective: To examine the performance of these markers for predicting the composite of dialysis requirement or in-hospital death in patients with an established diagnosis of AKI.Materials and methods: Prospective cohort study of 245 adults with AKI. A single urinary alpha-GST and pi-GST measurement was obtained at time of nephrology consultation.Results: Overall, urinary pi-GST performed better than alpha-GST for prediction of dialysis requirement (AUC 0.59 vs. 0.56), and the composite outcome (AUC 0.58 vs. 0.56). in subgroup analyses, pi-GST displayed better discrimination for prediction of dialysis requirement in patients with baseline eGFR < 60 mL/min/1.73 m(2) (AUC 0.61) and oliguria (AUC 0.72). Similarly, alpha-GST performed better in patients with stage-1 (AUC 0.66) and stage-2 AKI (AUC 0.80).Conclusions: in patients with an established diagnosis of AKI, a single urinary pi-GST measurement performed better than alpha-GST at predicting dialysis requirement or death, but neither marker had good prognostic discrimination.en
dc.description.affiliationSt Elizabeths Med Ctr, Kidney & Dialysis Res Lab, Brighton, MA 02135 USA
dc.description.affiliationTufts Univ, Sch Med, Dept Med, Boston, MA 02111 USA
dc.description.affiliationUniversidade Federal de São Paulo, Div Nephrol, São Paulo, Brazil
dc.description.affiliationTufts Med Ctr, Biostat Res Ctr, Boston, MA USA
dc.description.affiliationKlinikum Coburg, Med Klin 3, Coburg, Germany
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Div Nephrol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipArgutus Medical, Ltd, Dublin, Ireland
dc.description.sponsorshipNational Institute of Diabetes and Digestive and Kidney Diseases
dc.description.sponsorshipInternational Society of Nephrology Commission for the Global Advancement of Nephrology (COMGAN)
dc.description.sponsorshipIDNational Institute of Diabetes and Digestive and Kidney Diseases: RO3-DK077751
dc.format.extent709-717
dc.identifierhttp://dx.doi.org/10.3109/1354750X.2011.631219
dc.identifier.citationBiomarkers. London: Informa Healthcare, v. 16, n. 8, p. 709-717, 2011.
dc.identifier.doi10.3109/1354750X.2011.631219
dc.identifier.issn1354-750X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34324
dc.identifier.wosWOS:000297225000012
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofBiomarkers
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectacute kidney injuryen
dc.subjectacute renal failureen
dc.subjectbiomarkeren
dc.subjectglutathione S-transferaseen
dc.subjectepidemiologyen
dc.subjectprognosisen
dc.titleUrinary alpha-GST and pi-GST for prediction of dialysis requirement or in-hospital death in established acute kidney injuryen
dc.typeinfo:eu-repo/semantics/article
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