Morphometric MRI features and surgical outcome in patients with epilepsy related to hippocampal sclerosis and low intellectual quotient

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dc.citation.volumev. 82
dc.contributor.authorGaça, Larissa Botelho [UNIFESP]
dc.contributor.authorGarcia, Maria Teresa Fernandes Castilho [UNIFESP]
dc.contributor.authorSandim, Gabriel Barbosa [UNIFESP]
dc.contributor.authorLeme, Idaiane Batista Assumption
dc.contributor.authorNoffs, Maria Helena Silva [UNIFESP]
dc.contributor.authorCarrete Junior, Henrique [UNIFESP]
dc.contributor.authorCenteno, Ricardo Silva [UNIFESP]
dc.contributor.authorSato, Joao Ricardo [UNIFESP]
dc.contributor.authorYacubian, Elza Márcia Targas [UNIFESP]
dc.coverageSan Diego
dc.date.accessioned2020-07-20T16:30:51Z
dc.date.available2020-07-20T16:30:51Z
dc.date.issued2018
dc.description.abstractObjective: The objectives of this study were to verify in a series of patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS) if those with low intellectual quotient (IQ) levels have more extended areas of atrophy compared with those with higher IQ levels and to analyze whether IQ could be a variable implicated on a surgical outcome. Material and methods: Patients (n = 106) with refractory MTLE-HS submitted to corticoamygdalohippocampectomy (CAH) (57 left mesial temporal lobe epilepsy (MILE): 45 males) were enrolled. To determine if the IQ was a predictor of seizure outcome, totally seizure-free (SF) versus nonseizure-free (NSF) patients were evaluated. FreeSurfer was used for cortical thickness and volume estimation, comparing groups with lower (<80) and higher IQ (90-109) levels. Results: In the whole series, 42.45% of patients were SF (Engel Class laen
dc.description.abstractn = 45), and 57.54% were NSF (n = 61). Total cortical volume was significantly reduced in the group with lower IQ (p = 0.01). Significant reductions in the left hemisphere included the following: rostral middle frontal (p = 0.001). insula (p = 0.002). superior temporal gyrus (p = 0.003), thalamus (p = 0.004), and precentral gyrus (p = 0.02)en
dc.description.abstractand those in the right hemisphere included the following: rostra! middle frontal (p = 0.003), pars orbitalis (p = 0.01), and insula (p = 0.02). Cortical thickness analysis also showed reductions in the right superior parietal gyrus in patients with lower IQ No significant relationship between IQ and seizure outcome was found. Conclusions: This is the first study of a series of patients with pure MTLE-HS, including those with low IQ and their morphometric magnetic resonance imaging (MRI) features using FreeSurfer. Although patients with lower intellectual scores presented more areas of brain atrophy, IQ was not a predictor of surgical outcome. therefore, when evaluating seizure follow-up, low IQ in patients with MTLE-HS might not contraindicate resective surgery. (C) 2018 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Neurol & Neurosurg, Unidade Pesquisa & Tratamento Epilepsias, Rua Pedro Toledo 650, BR-04039002 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Diagnost Imaging, Rua Napoleao Barros 800, BR-04024002 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Rua Borges Lagoa 570, BR-04038000 Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Math Comp & Cognit, Ave Estados 501, BR-09210580 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFFSP, Dept Neurol & Neurosurg, Unidade Pesquisa & Tratamento Epilepsias, Rua Pedro Toledo 650, BR-04039002 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Diagnost Imaging, Rua Napoleao Barros 800, BR-04024002 Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Psychiat, Rua Borges Lagoa 570, BR-04038000 Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.format.extent144-149
dc.identifierhttp://dx.doi.org/10.1016/j.yebeh.2018.03.011
dc.identifier.citationEpilepsy & Behavior. San Diego, v. 82, p. 144-149, 2018.
dc.identifier.doi10.1016/j.yebeh.2018.03.011
dc.identifier.issn1525-5050
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55557
dc.identifier.wosWOS:000432591100023
dc.language.isoeng
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofEpilepsy & Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectMesial temporal lobe epilepsyen
dc.subjectHippocampal sclerosisen
dc.subjectFreeSurfer analysisen
dc.subjectSurgical outcomeen
dc.subjectLow IQen
dc.titleMorphometric MRI features and surgical outcome in patients with epilepsy related to hippocampal sclerosis and low intellectual quotienten
dc.typeinfo:eu-repo/semantics/article
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