Expression of ck-19, galectin-3 and hbme-1 in the differentiation of thyroid lesions: systematic review and diagnostic meta-analysis

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dc.contributor.authorMatos, Leandro Luongo de [UNIFESP]
dc.contributor.authorDel Giglio, Adriana Braz
dc.contributor.authorMatsubayashi, Carolina Ogawa
dc.contributor.authorFarah, Michelle de Lima
dc.contributor.authorDel Giglio, Auro
dc.contributor.authorPinhal, Maria Aparecida da Silva [UNIFESP]
dc.contributor.institutionFac Med ABC
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionAlbert Einstein Jewish Hosp
dc.date.accessioned2016-01-24T14:27:34Z
dc.date.available2016-01-24T14:27:34Z
dc.date.issued2012-08-13
dc.description.abstractBackground: To distinguish between malignant and benign lesions of the thyroid gland histological demonstration is often required since the fine-needle aspiration biopsy method applied pre-operatively has some limitations. in an attempt to improve diagnostic accuracy, markers using immunocytochemistry and immunohistochemistry techniques have been studied, mainly cytokeratin-19 (CK-19), galectin-3 (Gal-3) and Hector Battifora mesothelial-1 (HBME-1). However, current results remain controversial. the aim of the present article was to establish the diagnostic accuracy of CK-19, Gal-3 and HBME-1 markers, as well as their associations, in the differentiation of malignant and benign thyroid lesions.Methods: A systematic review of published articles on MEDLINE and the Cochrane Library was performed. After establishing inclusion and exclusion criteria, 66 articles were selected. the technique of meta-analysis of diagnostic accuracy was employed and global values of sensitivity, specificity, area under the summary ROC curve, and diagnostic odds ratio (dOR) were calculated.Results: for the immunohistochemistry technique, the positivity of CK-19 for the diagnosis of malignant thyroid lesions demonstrated global sensitivity of 81% and specificity of 73%; for Gal-3, sensitivity of 82% and specificity of 81%; and for HBME-1, sensitivity of 77% and specificity of 83%. the association of the three markers determined sensitivity of 85%, specificity of 97%, and diagnostic odds ratio of 95.1. Similar results were also found for the immunocytochemistry assay.Conclusion: This meta-analysis demonstrated that the three immunomarkers studied are accurate in pre- and postoperative diagnosis of benign and malignant thyroid lesions. Nevertheless, the search for other molecular markers must continue in order to enhance this diagnostic accuracy since the results found still show a persistency of false-negative and false-positive tests.en
dc.description.affiliationFac Med ABC, Dept Biochem, Santo Andre, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biochem, São Paulo, Brazil
dc.description.affiliationFac Med ABC, Dept Head & Neck Surg, Santo Andre, Brazil
dc.description.affiliationFac Med ABC, Med Sch Students, Santo Andre, Brazil
dc.description.affiliationFac Med ABC, Dept Hematol & Oncol, Santo Andre, Brazil
dc.description.affiliationAlbert Einstein Jewish Hosp, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biochem, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent10
dc.identifier0
dc.identifier.citationDiagnostic Pathology. London: Biomed Central Ltd, v. 7, 10 p., 2012.
dc.identifier.doi10.1186/1746-1596-7-97
dc.identifier.fileWOS000312600900001.pdf
dc.identifier.issn1746-1596
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35174
dc.identifier.wosWOS:000312600900001
dc.language.isoeng
dc.publisherBiomed Central Ltd
dc.relation.ispartofDiagnostic Pathology
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTumor markersen
dc.subjectBiologicalen
dc.subjectGalectin 3en
dc.subjectKeratin 19en
dc.subjectHBME-1 antigenen
dc.subjectThyroiden
dc.subjectReviewen
dc.titleExpression of ck-19, galectin-3 and hbme-1 in the differentiation of thyroid lesions: systematic review and diagnostic meta-analysisen
dc.typeinfo:eu-repo/semantics/article
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