Functional specializations within the tectum defense systems of the rat

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dc.contributor.authorSchenberg, L. C.
dc.contributor.authorPovoa, RMF
dc.contributor.authorCosta, ALP
dc.contributor.authorCaldellas, A. V.
dc.contributor.authorTufik, S.
dc.contributor.authorBittencourt, A. S.
dc.contributor.institutionUniv Fed Espirito Santo
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:37:34Z
dc.date.available2016-01-24T12:37:34Z
dc.date.issued2005-01-01
dc.description.abstractHere we review the differential contribution of the periaqueductal gray matter (PAG) and superior colliculus (SC) to the generation of rat defensive behaviors. the results of studies involving sine-wave and rectangular pulse electrical stimulation and chemical (NMDA) stimulation are summarized. Stimulation of SC and PAG produced freezing and flight behaviors along with exophthalmus (fully opened bulged eyes), micturition and defecation. the columnar organization of the PAG was evident in the results obtained. Defecation was elicited primarily by lateral PAG stimulation, while the remaining defensive behaviors were similarly elicited by lateral and dorsolateral PAG stimulation, although with the lowest thresholds in the dorsolateral column. Conversely, the ventrolateral PAG did not appear to participate in unconditioned defensive behaviors, which were only elicited by high intensity stimulation likely to encroach on adjacent regions. in the SC, the most important differences relative to the PAG were the lack of stimulation -evoked jumping in both intermediate and deep layers, and of NMDA-evoked galloping in intermediate layers. Therefore, we conclude that the SC may be only involved in the increased attentiveness (exophthalmus, immobility) and restlessness (trotting) of prey species exposed to the cues of a nearby predator. These responses may be distinct from the full-blown flight reaction that is mediated by the dorsolateral and lateral PAG. However, other evidences suggest the possible influences of stimulation schedule, environment dimensions and rat strain in determining outcomes. Overall our results suggest a dynamically organized representation of defensive behaviors in the midbrain tectum. (c) 2005 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Fed Espirito Santo, Dept Ciencias Fisiol, Ctr Biomed, Edificio Programa Pos Grad Ciencias Fisiol, BR-29043125 Vitoria, ES, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psicobiol, São Paulo, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Psicobiol, São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent1279-1298
dc.identifierhttp://dx.doi.org/10.1016/j.neubiorev.2005.05.006
dc.identifier.citationNeuroscience and Biobehavioral Reviews. Oxford: Pergamon-Elsevier B.V., v. 29, n. 8, p. 1279-1298, 2005.
dc.identifier.doi10.1016/j.neubiorev.2005.05.006
dc.identifier.issn0149-7634
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/28085
dc.identifier.wosWOS:000233140100013
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience and Biobehavioral Reviews
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectperiaqueductal grayen
dc.subjectsuperior colliculusen
dc.subjectNMDAen
dc.subjectfreezingen
dc.subjectflighten
dc.subjectmicturitionen
dc.subjectdefecationen
dc.subjectWistar ratsen
dc.subjectwild ratsen
dc.titleFunctional specializations within the tectum defense systems of the raten
dc.typeinfo:eu-repo/semantics/article
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