Hippocampal volume and the rapid antidepressant effect of ketamine

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dc.contributor.authorAbdallah, Chadi G.
dc.contributor.authorSalas, Ramiro
dc.contributor.authorJackowski, Andrea [UNIFESP]
dc.contributor.authorBaldwin, Philip
dc.contributor.authorSato, Joao R. [UNIFESP]
dc.contributor.authorMathew, Sanjay J.
dc.contributor.institutionNatl Ctr Posttraumat Stress Disorder PtSD
dc.contributor.institutionYale Univ
dc.contributor.institutionBaylor Coll Med
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.contributor.institutionMichael E Debakey Vet Adm VA Med Ctr
dc.date.accessioned2016-01-24T14:40:30Z
dc.date.available2016-01-24T14:40:30Z
dc.date.issued2015-05-01
dc.description.abstractAccumulating evidence underscores the utility of ketamine in treating severely treatment-resistant depressed patients. We investigated the relationship between the rapid antidepressant effects of ketamine and hippocampal volume, a biomarker of antidepressant treatment outcome. We gave 16 medication-free, major depressive disorder (MDD) patients a single, sub-anesthetic dose infusion of ketamine (0.5 mg/kg, over 40 min). We assessed depression severity pre-treatment, and at 24 h post-treatment, with the Montgomery-angstrom sberg Depression Rating Scale (MADRS). Prior to treatment, patients underwent magnetic resonance imaging (MRI) to estimate their hippocampal volume: We obtained viable MRI data in 13 patients. Delta MADRS (post- minus pre-treatment) was significantly correlated with the pre-treatment volumes of the left hippocampus (r = 0.66; p = 0.01), but not the right hippocampus (r = 0.49; p = 0.09). the correlation between delta MADRS and the left hippocampus remained high (r > 0.6; p = 0.13), after controlling for several demographic and clinical variables, although the p value increased due to the reduced degree of freedom (df = 5). Ketamine exerts enhanced antidepressant effects in patients with a relatively smaller hippocampus, a patient population that has been repeatedly shown to be refractory to traditional antidepressants.en
dc.description.affiliationNatl Ctr Posttraumat Stress Disorder PtSD, Clin Neurosci Div, West Haven, CT USA
dc.description.affiliationYale Univ, Sch Med, Dept Psychiat, New Haven, CT USA
dc.description.affiliationBaylor Coll Med, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationUniv Fed ABC, Ctr Math Computat & Cognit, Santo Andre, Brazil
dc.description.affiliationMichael E Debakey Vet Adm VA Med Ctr, Mental Hlth Care Line, Houston, TX USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipClinical Neuroscience Division of the Veteran's Administration (VA) National Center for PTSD
dc.description.sponsorshipAmerican Psychiatric Foundation (APF Early Academic Career Award
dc.description.sponsorshipThe Brain and Behavior Research Foundation (NARSAD Independent Investigator and NARSAD New Investigator Awards)
dc.description.sponsorshipThe Brown Foundation and the Michael E Debakey VA Medical Center
dc.description.sponsorshipIDClinical Neuroscience Division of the Veteran's Administration (VA) National Center for PTSD: K23 MH-101498
dc.description.sponsorshipIDClinical Neuroscience Division of the Veteran's Administration (VA) National Center for PTSD: R01 MH-081870
dc.format.extent591-595
dc.identifierhttp://dx.doi.org/10.1177/0269881114544776
dc.identifier.citationJournal of Psychopharmacology. London: Sage Publications Ltd, v. 29, n. 5, p. 591-595, 2015.
dc.identifier.doi10.1177/0269881114544776
dc.identifier.issn0269-8811
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/39088
dc.identifier.wosWOS:000354903600008
dc.language.isoeng
dc.publisherSage Publications Ltd
dc.relation.ispartofJournal of Psychopharmacology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.uk.sagepub.com/aboutus/openaccess.htm
dc.subjectAntidepressanten
dc.subjectdepressionen
dc.subjecthippocampusen
dc.subjectketamineen
dc.subjectmagnetic resonance imagingen
dc.subjectmajor depressive disorderen
dc.subjectrefractory patientsen
dc.titleHippocampal volume and the rapid antidepressant effect of ketamineen
dc.typeinfo:eu-repo/semantics/article
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