Cytotoxic effects of dillapiole on MDA-MB-231 cells involve the induction of apoptosis through the mitochondrial pathway by inducing an oxidative stress while altering the cytoskeleton network

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dc.contributor.authorFerreira, Adilson Kleber
dc.contributor.authorde-Sa-Junior, Paulo Luiz
dc.contributor.authorPasqualoto, Kerly Fernanda Mesquita
dc.contributor.authorAzevedo, Ricardo Alexandre de
dc.contributor.authorDias Camara, Diana Aparecida
dc.contributor.authorCosta, Andre Santos
dc.contributor.authorFigueiredo, Carlos Rogerio [UNIFESP]
dc.contributor.authorMatsuo, Alisson Leonardo [UNIFESP]
dc.contributor.authorMassaoka, Mariana Hiromi [UNIFESP]
dc.contributor.authorVatti Auada, Aline Vivian
dc.contributor.authorLebrun, Ivo
dc.contributor.authorCosta Bernstorff Damiao, Mariana Celestina Frojuello
dc.contributor.authorTavares, Mauricio Temotheo
dc.contributor.authorMotter Magri, Fatima Maria
dc.contributor.authorKerkis, Irina
dc.contributor.authorParise Filho, Roberto
dc.contributor.institutionButantan Inst
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Prebiteriana Mackenzie
dc.date.accessioned2016-01-24T14:35:31Z
dc.date.available2016-01-24T14:35:31Z
dc.date.issued2014-04-01
dc.description.abstractBreast cancer is the world's leading cause of death among women. This situation imposes an urgent development of more selective and less toxic agents. the use of natural molecular fingerprints as sources for new bioactive chemical entities has proven to be a quite promising and efficient method. Here, we have demonstrated for the first time that dillapiole has broad cytotoxic effects against a variety tumor cells. for instance, we found that it can act as a pro-oxidant compound through the induction of reactive oxygen species (ROS) release in MDA-MB-231 cells. We also demonstrated that dillapiole exhibits antiproliferative properties, arresting cells at the G0/G1 phase and its antimigration effects can be associated with the disruption of actin filaments, which in turn can prevent tumor cell proliferation. Molecular modeling studies corroborated the biological findings and suggested that dillapiole may present a good pharmacokinetic profile, mainly because its hydrophobic character, which can facilitate its diffusion through tumor cell membranes. All these findings support the fact that dillapiole is a promising anticancer agent. (C) 2013 Elsevier Masson SAS. All rights reserved.en
dc.description.affiliationButantan Inst, Genet Lab, BR-05503900 São Paulo, Brazil
dc.description.affiliationButantan Inst, Biochem & Biophys Lab, BR-05503900 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Microbiol Immunol & Parasitol Dept, Expt Oncol Unit UNONEX, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Pharmaceut Sci, Dept Pharm, BR-05508000 São Paulo, Brazil
dc.description.affiliationUniv Prebiteriana Mackenzie, Ctr Biol Sci & Hlth CCBS, BR-01302907 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Microbiol Immunol & Parasitol Dept, Expt Oncol Unit UNONEX, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipProvost's Office for Research of University of São Paulo
dc.format.extent195-207
dc.identifierhttp://dx.doi.org/10.1016/j.biochi.2013.12.008
dc.identifier.citationBiochimie. Paris: Elsevier France-editions Scientifiques Medicales Elsevier, v. 99C, p. 195-207, 2014.
dc.identifier.doi10.1016/j.biochi.2013.12.008
dc.identifier.issn0300-9084
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37608
dc.identifier.wosWOS:000332822100023
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBiochimie
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectPiper aduncumen
dc.subjectDillapioleen
dc.subjectAntitumoralen
dc.subjectApoptosisen
dc.subjectCell cycleen
dc.subjectROSen
dc.subjectMolecular modelingen
dc.titleCytotoxic effects of dillapiole on MDA-MB-231 cells involve the induction of apoptosis through the mitochondrial pathway by inducing an oxidative stress while altering the cytoskeleton networken
dc.typeinfo:eu-repo/semantics/article
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