Pulmonary complications in patients with antibody deficiency

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dc.contributor.authorCosta-Carvalho, Beatriz T. [UNIFESP]
dc.contributor.authorWandalsen, Gustavo F. [UNIFESP]
dc.contributor.authorPulici, Guilherme [UNIFESP]
dc.contributor.authorAranda, Carolina Sanchez [UNIFESP]
dc.contributor.authorSole, Dirceu [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:16:42Z
dc.date.available2016-01-24T14:16:42Z
dc.date.issued2011-05-01
dc.description.abstractObjective: the aim of this study was to evaluate pulmonary complications in patients with primary antibody deficiency (X-linked agammaglobulinaemia [XLA] and common variable immunodeficiency [CVID]).Methods: Thirty patients over six years of age regularly followed in a reference out-patient clinic on primary immunodeficiency were studied. All of them have been treated with intravenous immunoglobulin (IVIG) replacement therapy. Pulmonary complications were evaluated analysing clinical data (medical records review), lung function test (spirometry) and pulmonary imaging (chest computed tomography [CCT]).Results: Patients with normal CCT (N=14) and those with abnormal CCT (N=16) have shown no differences regarding the age at onset of symptoms, age of diagnosis, and duration of IVIG treatment. the mean number of pneumonia episodes before IVIG replacement was significantly higher among patients with abnormal CCT (4 vs 7 episodes, p=0.008). CCT abnormalities observed in 16 patients were: bronchiectasis (12/16); peribronchial thickening (3/16); air trapping (5/16); lung volume reduction (4/16); atelectasis (2/16), follicular bronchiolitis and ground-glass abnormality (2/16) and parenchyma nodule (1/16). Lung function tests showed ventilatory disturbance in 18/30: obstructive pattern in 38.8%, restrictive pattern in 44.4%, and mix pattern in 16.7%. There were no significant differences in lung function between those with and without CCT abnormalities. Negative significant correlations were observed between lung function and number of episodes of pneumonia. Chronic persistent cough was associated with a reduction in lung function.Conclusions: Pulmonary complications are not rare in patients with antibody deficiencies and they must be monitored. (C) 2010 SEICAP. Published by Elsevier Espana, S.L. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pediat, Div Allergy Clin Immunol & Rheumatol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent128-132
dc.identifierhttp://dx.doi.org/10.1016/j.aller.2010.12.003
dc.identifier.citationAllergologia Et Immunopathologia. Barcelona: Elsevier Doyma Sl, v. 39, n. 3, p. 128-132, 2011.
dc.identifier.doi10.1016/j.aller.2010.12.003
dc.identifier.issn0301-0546
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33673
dc.identifier.wosWOS:000291283000003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofAllergologia Et Immunopathologia
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectAgammaglobulinaemiaen
dc.subjectCommon variable immunodeficiencyen
dc.subjectHumoral immunodeficiencyen
dc.subjectBronchiectasisen
dc.subjectLung functionen
dc.titlePulmonary complications in patients with antibody deficiencyen
dc.typeinfo:eu-repo/semantics/article
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