Differences in synthesis and absorption of cholesterol of two effective lipid-lowering therapies

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dc.contributor.authorKasmas, Soraia Hani [UNIFESP]
dc.contributor.authorIzar, Maria Cristina de Oliveira [UNIFESP]
dc.contributor.authorFrança, Carolina Nunes [UNIFESP]
dc.contributor.authorRamos, Silvia Cristina [UNIFESP]
dc.contributor.authorMoreira, Flávio Tocci [UNIFESP]
dc.contributor.authorHelfenstein, Tatiana [UNIFESP]
dc.contributor.authorMoreno, Ronilson Agnaldo
dc.contributor.authorBorges, Ney Carter do Carmo
dc.contributor.authorFigueiredo Neto, Antonio Martins
dc.contributor.authorFonseca, Francisco Antonio Helfenstein [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInstituto Nacional de Ciência e Tecnologia de Fluidos Complexos
dc.contributor.institutionSynchrophar
dc.date.accessioned2015-06-14T13:45:02Z
dc.date.available2015-06-14T13:45:02Z
dc.date.issued2012-11-01
dc.description.abstractEffective statin therapy is associated with a marked reduction of cardiovascular events. However, the explanation for full benefits obtained for LDL cholesterol targets by combined lipid-lowering therapy is controversial. Our study compared the effects of two equally effective lipid-lowering strategies on markers of cholesterol synthesis and absorption. A prospective, open label, randomized, parallel design study, with blinded endpoints, included 116 subjects. We compared the effects of a 12-week treatment with 40 mg rosuvastatin or the combination of 40 mg simvastatin/10 mg ezetimibe on markers of cholesterol absorption (campesterol and β-sitosterol), synthesis (desmosterol), and their ratios to cholesterol. Both therapies similarly decreased total and LDL cholesterol, triglycerides and apolipoprotein B, and increased apolipoprotein A1 (P < 0.05 vs baseline for all). Simvastatin/ezetimibe increased plasma desmosterol (P = 0.012 vs baseline), and decreased campesterol and β-sitosterol (P < 0.0001 vs baseline for both), with higher desmosterol (P = 0.007) and lower campesterol and β-sitosterol compared to rosuvastatin, (P < 0.0001, for both). In addition, rosuvastatin increased the ratios of these markers to cholesterol (P < 0.002 vs baseline for all), whereas simvastatin/ezetimibe significantly decreased the campesterol/cholesterol ratio (P = 0.008 vs baseline) and tripled the desmosterol/cholesterol ratio (P < 0.0001 vs baseline). The campesterol/cholesterol and β-sitosterol/cholesterol ratios were lower, whereas the desmosterol/cholesterol ratio was higher in patients receiving simvastatin/ezetimibe (P < 0.0001 vs rosuvastatin, for all). Pronounced differences in markers of cholesterol absorption and synthesis were observed between two equally effective lipid-lowering strategies.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Medicina Divisão de Cardiologia
dc.description.affiliationInstituto Nacional de Ciência e Tecnologia de Fluidos Complexos
dc.description.affiliationSynchrophar
dc.description.affiliationUnifespUNIFESP, Depto. de Medicina Divisão de Cardiologia
dc.description.sourceSciELO
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFAPESP: 2008/55443-6
dc.description.sponsorshipIDFAPESP: 2008/52597-2
dc.description.sponsorshipIDCNPq: 2008/57685-7
dc.format.extent1095-1101
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2012007500118
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 45, n. 11, p. 1095-1101, 2012.
dc.identifier.doi10.1590/S0100-879X2012007500118
dc.identifier.fileS0100-879X2012001100015.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2012001100015
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/7380
dc.identifier.wosWOS:000309470400015
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCampesterolen
dc.subjectβ-sitosterolen
dc.subjectDesmosterolen
dc.subjectStatinen
dc.subjectEzetimibeen
dc.titleDifferences in synthesis and absorption of cholesterol of two effective lipid-lowering therapiesen
dc.typeinfo:eu-repo/semantics/article
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