The Edinger-Westphal nucleus II: Hypothalamic afferents in the rat

Página do item simplificado
dc.contributor.authorSilva, Andre V. da
dc.contributor.authorTorres, Kelly R.
dc.contributor.authorHaemmerle, Carlos A.
dc.contributor.authorCéspedes, Isabel Cristina [UNIFESP]
dc.contributor.authorBittencourt, Jackson C.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:34:48Z
dc.date.available2016-01-24T14:34:48Z
dc.date.issued2013-12-01
dc.description.abstractNumerous functions have been attributed to the Edinger-Westphal nucleus (EW), including those related to feeding behavior, pain control, alcohol consumption and the stress response. the LW is thought to consist of two parts: one controls accommodation, choroidal blood flow and pupillary constriction, primarily comprising cholinergic cells and projecting to the ciliary ganglion; and the other would be involved in the non-ocular functions mentioned above, comprising peptide-producing neurons and projecting to the brainstem, spinal cord and prosencephalic regions. Despite the fact that the EW is well known, its connections have yet to be described in detail. the aim of this work was to produce a map of the hypothalamic sources of afferents to the EW in the rat. We injected the retrograde tracer Fluoro-Gold into the EW, and using biotinylated dextran amine, injected into afferent sources as the anterograde control. We found retrogradely labeled cells in the following regions: subfornical organ, paraventricular hypothalamic nucleus, arcuate nucleus, lateral hypothalamic area, zona incerta, posterior hypothalamic nucleus, medial vestibular nucleus and cerebellar interpositus nucleus. After injecting BDA into the paraventricular hypothalamic nucleus, lateral hypothalamic area and posterior hypothalamic nucleus, we found anterogradely labeled fibers in close apposition to and potential synaptic contact with urocortin 1-immunoreactive cells in the EW. On the basis of our findings, we can suggest that the connections between the EW and the hypothalamic nuclei are involved in controlling stress responses and feeding behavior. (C) 2013 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Anatomy, Lab Chem Neuroanat, BR-05508000 São Paulo, Brazil
dc.description.affiliationSão Paulo State Univ, Inst Biosci, Dept Anat, BR-18618970 Botucatu, SP, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biomed Sci, BR-11060001 Santos, Brazil
dc.description.affiliationUniv São Paulo, Ctr Neurosci & Behav, Inst Psychol, BR-05508000 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biomed Sci, BR-11060001 Santos, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 2004/13849-5
dc.description.sponsorshipIDFAPESP: 2007/57020-2
dc.format.extent5-19
dc.identifierhttps://dx.doi.org/10.1016/j.jchemneu.2013.04.001
dc.identifier.citationJournal of Chemical Neuroanatomy. Amsterdam: Elsevier B.V., v. 54, p. 5-19, 2013.
dc.identifier.doi10.1016/j.jchemneu.2013.04.001
dc.identifier.issn0891-0618
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/37039
dc.identifier.wosWOS:000330089200002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of Chemical Neuroanatomy
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectUrocortin 1en
dc.subjectAfferentsen
dc.subjectCorticotropin-releasing factoren
dc.subjectNeuronal tracersen
dc.subjectLong-Evans ratsen
dc.subjectStress responseen
dc.titleThe Edinger-Westphal nucleus II: Hypothalamic afferents in the raten
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
ISS - Artigos