Serum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: The relationship of homocysteine with other cardiovascular risk factors

Página do item simplificado
dc.contributor.authorTavares, Edelweiss Fonseca [UNIFESP]
dc.contributor.authorVieira Filho, João Paulo Botelho [UNIFESP]
dc.contributor.authorAndriolo, Adagmar [UNIFESP]
dc.contributor.authorPerez, Ana Beatriz Alvarez [UNIFESP]
dc.contributor.authorVergani, Naja [UNIFESP]
dc.contributor.authorSanudo, Adriana [UNIFESP]
dc.contributor.authorGimeno, Suely Godoy Agostinho [UNIFESP]
dc.contributor.authorFranco, Laercio Joel [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T17:17:33Z
dc.date.available2018-06-15T17:17:33Z
dc.date.issued2004-12-01
dc.description.abstractHyperhomocysteinemia is a risk factor for cardiovascular disease. C677T mutation at the MTHFR gene and deficiencies of folic acid and vitamin B-12 may account for elevation of total homocysteine (tHcy). Ninety Brazilian Parka-teje Indians (90.0% of the population without admixture, aged greater than or equal to20 years) were studied. Hyperhomocysteinemia was observed in 26.7% of the Indians. No case of vitamin B-12 deficiency was detected. Folic acid deficiency was found in 43.3% of the subjects. Rates of mutated allele 677T and TT genotype were 40.7% and 14.0%, respectively. Prevalence of hypertension, dyslipidemia, smoking, WHIR greater than or equal to0.9, BMI greater than or equal to25 kg/m(2) and chronic alcohol use were 4.4%, 44.4%, 25.6%, 72.2%, 67.8%, and 0.0%, respectively. All creatinine values were normal. Natural logarithmic (In) tHcy showed no correlation with age, but was positively correlated with systolic (r=0.22) and diastolic (r=0.21) blood pressure and triglycerides (r=0.39) and inversely correlated with folic acid (r= -0.40) adjusted for age and sex. Total homocysteine (tHcy) was higher among TT genotype (P<.001). The multiple linear regression model, containing variables for sex, folic acid, TT genotype, and triglycerides, explained 50.0% of the variation of the In tHcy. in summary, high rates of cardiovascular risk factors were discovered. C667T mutation and folic acid deficiency can explain, at least in part, the observed hyperhomocysteinemia.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Prevent Med, BR-04023038 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Endocrinol Sect, BR-04023038 Sao Paulo, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Clin Pathol Sect, Dept Med, Med Genet Ctr Morphol & Pediat, BR-04023038 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Prevent Med, BR-04023038 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Endocrinol Sect, BR-04023038 Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Clin Pathol Sect, Dept Med, Med Genet Ctr Morphol & Pediat, BR-04023038 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent49-56
dc.identifier.citationEthnicity & Disease. Atlanta: Int Soc Hypertension Blacks-ishib, v. 14, n. 1, p. 49-56, 2004.
dc.identifier.issn1049-510X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43575
dc.identifier.wosWOS:000220239600009
dc.language.isoeng
dc.publisherInt Soc Hypertension Blacks-ishib
dc.relation.ispartofEthnicity & Disease
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectBrazilian Indiansen
dc.subjectC677T mutationen
dc.subjectcardiovascular risk factorsen
dc.subjectfolic aciden
dc.subjecthomocysteineen
dc.subjectMTHFRen
dc.subjectvitamin B-12en
dc.titleSerum total homocysteine levels and the prevalence of folic acid deficiency and C677T mutation at the MTHFR gene in an indigenous population of Amazonia: The relationship of homocysteine with other cardiovascular risk factorsen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos