Performance evaluation of cryo laser phoresis technique as biophysical method to promote diclofenac sodium cutaneous perfusion

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dc.contributor.authorAndreo, Marcio Adriano [UNIFESP]
dc.contributor.authorRufino, Iasmin Mimoto [UNIFESP]
dc.contributor.authorde Orue Ubaldo, Daniela Cecilia Ortiz [UNIFESP]
dc.contributor.authorHerbst, Estela Boaro [UNIFESP]
dc.contributor.authorTorres da Silva, Heron Dominguez [UNIFESP]
dc.contributor.authorde Oliveira, Pedro Goncalves
dc.contributor.authorFerrari, Marcio
dc.contributor.authorPires Rosa, Paulo Cesar
dc.contributor.authorLopes, Patricia Santos [UNIFESP]
dc.contributor.authorLeite-Silva, Vania Rodrigues [UNIFESP]
dc.date.accessioned2019-01-21T10:29:49Z
dc.date.available2019-01-21T10:29:49Z
dc.date.issued2016
dc.description.abstractAiming to alter and/or improve permeation of active compounds in the skin, many strategies have been developed, including biophysical methods. One of the physical absorption techniques, currently known as Cryo Laser Phoresis (CLP), consists of an apparatus that emits radiation on polar or nonpolar molecules of the active substance, resulting in faster penetration when in comparison to the standard topical application. The goal of this work was to evaluate the efficacy of a method that proposes to increase cutaneous permeation of diclofenac sodium by using CLP technique. The influence on permeation was evaluated ex vivo, using Franz cell and human skin obtained from cosmetic surgery. The results were evaluated using statistical methods and data exploratory analysis: clusters, k-means and Principal Component Analysis. The results showed a larger increase in the concentration of diclofenac sodium in the dermis with the use of laser. In all samples (with or without laser application) it was observed that skin surface showed an amount of diclofenac sodium and that there was no active passage to the receptor liquid, suggesting that diclofenac sodium was not absorbed. These results indicate that CLP, when used under the conditions described in this study, is able to increase diclofenac sodium penetration and its retention into deeper layers.en
dc.description.affiliationInstitute of Environment, Chemistry and Pharmaceutical Sciences, Federal University of São Paulo Diadema, SP, Brazil
dc.description.affiliationFaculty of Pharmacy, Anhembi Morumbi, University, São Paulo, SP, Brazil
dc.description.affiliationDepartment of Pharmacy, Federal University of Rio Grande do Norte, Natal, RN, Brazil
dc.description.affiliationFaculty of Pharmaceutical Sciences State University of Campinas, Campinas, SP, Brazil
dc.description.affiliationUnifespInstitute of Environment, Chemistry and Pharmaceutical Sciences, Federal University of São Paulo Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent69-76
dc.identifierhttp://dx.doi.org/10.1590/S1984-82502016000100008
dc.identifier.citationBrazilian Journal Of Pharmaceutical Sciences. Sao paulo, v. 52, n. 1, p. 69-76, 2016.
dc.identifier.doi10.1590/S1984-82502016000100008
dc.identifier.fileS1984-82502016000100008.pdf
dc.identifier.issn1984-8250
dc.identifier.scieloS1984-82502016000100008
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49409
dc.identifier.wosWOS:000383164300008
dc.language.isoeng
dc.publisherAssoc Brasileira Psiquiatria
dc.relation.ispartofBrazilian Journal Of Pharmaceutical Sciences
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectCryo Laser Phoresis/Dematologic Useen
dc.subjectCutaneous Permeationen
dc.subjectDiclofenac Sodium/Cutaneous Permeationen
dc.subjectFranz CellPermeationen
dc.subjectSkinen
dc.subjectFormulationsen
dc.subjectPenetrationen
dc.subjectDeliveryen
dc.subjectSystemen
dc.titlePerformance evaluation of cryo laser phoresis technique as biophysical method to promote diclofenac sodium cutaneous perfusionen
dc.typeinfo:eu-repo/semantics/article
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