Prognostic significance of CD24 and claudin-7 immunoexpression in ductal invasive breast cancer

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dc.contributor.authorBernardi, M. A.
dc.contributor.authorLogullo, Angela Flavia [UNIFESP]
dc.contributor.authorPasini, F. S.
dc.contributor.authorNonogaki, S.
dc.contributor.authorBlumke, C.
dc.contributor.authorSoares, F. A.
dc.contributor.authorBrentani, M. M.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionAC Camargo Hosp
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionAdolfo Lutz Inst
dc.contributor.institutionUninove Univ
dc.date.accessioned2016-01-24T14:17:39Z
dc.date.available2016-01-24T14:17:39Z
dc.date.issued2012-01-01
dc.description.abstractThis study aimed to identify the CD24 and CD44 immunophenotypes within invasive ductal breast carcinoma (I DC) subgroups defined by immunohistochesmistry markers and to determine its influence on prognosis as well as its association with the expression of Ki-67, cytokeratins (CK5 and CK 18) and claudin-7. Immunohistochemical expression of CD44 and CD24 alone or in combination was investigated in 95 IDC cases arranged in a tissue microarray (TMA). the association with subgroups defined as luminal A and B; HER2 rich and triple negative, or with the other markers and prognosis was analyzed. CD44(+)/CD24(-) and CD44(-)/CD24(+) were respectively present in 8.4% and 16.8% of the tumors, a lack of both proteins was detected in 6.3%, while CD441(-)/CD24(+) was observed in 45.3% of the tumors. Although there was no significant correlation between subgroups and different phenotypes, the CD44(+)/CD24(-) phenotype was more common in the basal subgroups but absent in HER2 tumors, whereas luminal tumors are enriched in CD44(-)/CD24(+) and CD44(+)/CD24(+) cells. the frequency of CD44(+)/CD24(-) or CD44(-)/CD24(+) was not associated with clinical characteristics or biological markers. There was also no significant association of these phenotypes with the event free (DFS) and overall survival (OS). Single CD44(+) was evident in 57.9% of the tumors and was marginally associated to grading and not to any other tumor characteristics as well as OS and DFS. CD24(+) was positive in 74.7% of the tumors, showing a significant association with estrogen receptor, progesterone receptor and Ki-67 and a marginal association with CKI8 and claudin-7. Expression of claudin-7 and Ki-67 did not associate with the cancer subgroups, while a positive association between CK18 and the luminal subgroups was found (P=0.03). CK5, CK18 and Ki-67 expression had no influence in OS or DFS. Single CD24(+) (P=0.07) and claudin-7 positivity (P=0.05) were associated with reduced time of recurrence, suggesting a contribution of these markers to aggressiveness of breast cancer.en
dc.description.affiliationUniv São Paulo, Sch Med, Radiol & Oncol Dept, BR-01240690 São Paulo, Brazil
dc.description.affiliationAC Camargo Hosp, Mastol Dept, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationAdolfo Lutz Inst, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUninove Univ, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent28-38
dc.identifierhttp://dx.doi.org/10.3892/or.2011.1477
dc.identifier.citationOncology Reports. Athens: Spandidos Publ Ltd, v. 27, n. 1, p. 28-38, 2012.
dc.identifier.doi10.3892/or.2011.1477
dc.identifier.issn1021-335X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/34405
dc.identifier.wosWOS:000297397500004
dc.language.isoeng
dc.publisherSpandidos Publ Ltd
dc.relation.ispartofOncology Reports
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectcancer stem cellen
dc.subjectCD24en
dc.subjectCD44en
dc.subjectclaudin-7en
dc.subjectprognosisen
dc.subjectbreast cancer subgroupsen
dc.titlePrognostic significance of CD24 and claudin-7 immunoexpression in ductal invasive breast canceren
dc.typeinfo:eu-repo/semantics/article
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