Indoleamine 2,3-dioxygenase (IDO) Activity in Placental Compartments of Renal-Transplanted Pregnant Women

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dc.contributor.authorPrado, Karen Matias do
dc.contributor.authorCorrea-Silva, Simone
dc.contributor.authorOliveira, Leandro Gustavo
dc.contributor.authorSaraiva Camara, Niels Olsen
dc.contributor.authorOno, Erica [UNIFESP]
dc.contributor.authorSandri, Silvana
dc.contributor.authorTourino, Melissa Cavalheiro
dc.contributor.authorCampa, Ana
dc.contributor.authorLima, Larissa de Sa
dc.contributor.authorScavone, Cristoforo
dc.contributor.authorBevilacqua, Estela
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:37:34Z
dc.date.available2016-01-24T14:37:34Z
dc.date.issued2014-07-01
dc.description.abstractProblem Immunosuppressive drugs change gestational IDO activity at the maternal-fetal interface. Method of Study Analysis of placental IDO expression and activity, interferon gamma (IFN-), and IL-10 expression and NFkB activity in renal transplant recipient women under immunosuppressive treatment. Results We demonstrated a significant reduction in IDO activity (P=0.0275) and expression (P=0.026) and in NFkB activity (P=0.0176) in the villous region of renal transplanted mother. These findings did not correlate with the higher serum levels of kynurenine (P=0.002). in the decidual compartment, IDO was immunolocalized mainly on the extravillous cytotrophoblast but did not show significant differences among the experimental groups; kynurenine was significantly higher (P=0.036) and was inversely proportional to the decidual IFN- profile (P=0.0433). No change was seen in IL-10 levels. NFkB activity was significantly higher in decidual compartment correlating with the higher IDO activity and suggesting that in immunosuppressant pregnancy, IDO activity and expression remain regulated by NFkB. Conclusion the increased IDO activity in decidua may indicate an attempt to offset the low expression. These findings call attention to the relevance of IDO activity at the maternal interface in pregnant transplant recipients, likely modulated by immunosuppressive agents and associated with a high risk of associated gestational disorders.en
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, São Paulo, Brazil
dc.description.affiliationUNESP São Paulo State Univ, Botucatu Med Sch, Postgrad Program Gynecol Obstet & Mastol, Botucatu, SP, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Immunol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Sch Med, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Pharmaceut Sci, Dept Clin & Toxicol Anal, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Dept Pharmacol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sch Med, Dept Pediat, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent45-56
dc.identifierhttp://dx.doi.org/10.1111/aji.12233
dc.identifier.citationAmerican Journal of Reproductive Immunology. Hoboken: Wiley-Blackwell, v. 72, n. 1, p. 45-56, 2014.
dc.identifier.doi10.1111/aji.12233
dc.identifier.issn1046-7408
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37969
dc.identifier.wosWOS:000337752700006
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofAmerican Journal of Reproductive Immunology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectIDOen
dc.subjectIFN-en
dc.subjectImmunosuppressive drugsen
dc.subjectKynurenineen
dc.subjectNF-Ben
dc.subjectPlacentaen
dc.titleIndoleamine 2,3-dioxygenase (IDO) Activity in Placental Compartments of Renal-Transplanted Pregnant Womenen
dc.typeinfo:eu-repo/semantics/article
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