Lipid levels and risk of recurrent venous thrombosis: results from the MEGA follow-up study

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dc.citation.issue4
dc.citation.volume15
dc.contributor.authorMorelli, V. M. [UNIFESP]
dc.contributor.authorLijfering, W. M.
dc.contributor.authorRosendaal, F. R.
dc.contributor.authorCannegieter, S. C.
dc.coverageHoboken
dc.date.accessioned2020-07-17T14:02:28Z
dc.date.available2020-07-17T14:02:28Z
dc.date.issued2017
dc.description.abstractBackground Knowledge of risk factors for recurrent venous thrombosis may guide decisions on duration of anticoagulation. The association between lipid levels and first venous thrombosis has been studied extensively. However, data on the role of lipids in the risk of recurrence are scarce. Objective To assess the association between lipid levels and recurrent venous thrombosis. Patients/Methods Patients with a first venous thrombosis from the MEGA study were included. Follow-up started at the date of end of anticoagulant treatment. Percentile categories of total/low-density lipoprotein/high-density lipoprotein cholesterol, triglycerides and apolipoproteins B and A1 were established (< 10th, 10th-25th, 25th-75th [reference], 75th-90th, > 90th percentile). Lipids were measured at least 3 months after discontinuing anticoagulation. Results Of 2106 patients followed for a median of 6.9 years, 326 developed recurrence (incidence rate, 2.7/100 patient-yearsen
dc.description.abstract95% confidence interval [CI], 2.5-3.1). With hazard ratios ranging from 0.88 (95% CI, 0.55-1.42) to 1.33 (95% CI, 0.86-2.04) in the highest percentile category vs. the reference, we found no association across percentile categories between recurrence and lipid levels in age- and sex-adjusted models, nor after further adjustments for body mass index, diabetes, estrogen and statin use, and duration of anticoagulation. Subgroup analyses stratified by unprovoked or provoked first events, location (deep vein thrombosis or pulmonary embolism) and sex also did not reveal an association with any of the lipid levels studied. Conclusions Testing lipid levels did not identify patients at an increased risk of recurrent venous thrombosis in this study, including those with unprovoked first events, and these should not influence decisions on duration of anticoagulation.en
dc.description.affiliationLeiden Univ, Dept Clin Epidemiol, Med Ctr, POB 9600, NL-2300 RC Leiden, Netherlands
dc.description.affiliationUniv Fed Sao Paulo, Dept Clin & Expt Oncol, Sao Paulo, Brazil
dc.description.affiliationLeiden Univ, Einthoven Lab Expt Vasc Med, Med Ctr, Leiden, Netherlands
dc.description.affiliationLeiden Univ, Dept Thrombosis & Hemostasis, Med Ctr, Leiden, Netherlands
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Clin & Expt Oncol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipNetherlands Heart Foundation
dc.description.sponsorshipDutch Cancer Foundation
dc.description.sponsorshipNetherlands Organization for Scientific Research
dc.description.sponsorshipIDNetherlands Heart Foundation: NHS98.113
dc.description.sponsorshipIDNetherlands Heart Foundation: NHS2010B167
dc.description.sponsorshipIDNetherlands Heart Foundation: NHS208B086
dc.description.sponsorshipIDNetherlands Heart Foundation: NHS2011T012
dc.description.sponsorshipIDDutch Cancer Foundation: RUL 99/1992
dc.description.sponsorshipIDNetherlands Organization for Scientific Research: 912-03-033\2003
dc.format.extent695-701
dc.identifierhttp://dx.doi.org/10.1111/jth.13640
dc.identifier.citationJournal Of Thrombosis And Haemostasis. Hoboken, v. 15, n. 4, p. 695-701, 2017.
dc.identifier.doi10.1111/jth.13640
dc.identifier.issn1538-7933
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54827
dc.identifier.wosWOS:000398623800013
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofJournal Of Thrombosis And Haemostasis
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectapolipoproteinsen
dc.subjectlipidsen
dc.subjectlipoproteinsen
dc.subjectrecurrenceen
dc.subjectvenous thrombosisen
dc.titleLipid levels and risk of recurrent venous thrombosis: results from the MEGA follow-up studyen
dc.typeinfo:eu-repo/semantics/article
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