Education, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck cancer

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dc.contributor.authorLópez, R.v.m.
dc.contributor.authorZago, M.a.
dc.contributor.authorEluf-Neto, J.
dc.contributor.authorCurado, M.p.
dc.contributor.authorDaudt, A.w.
dc.contributor.authorDa Silva-Junior, W.a.
dc.contributor.authorZanette, D.l.
dc.contributor.authorLevi, J.e.
dc.contributor.authorDe Carvalho, M.b.
dc.contributor.authorKowalski, Luiz Paulo [UNIFESP]
dc.contributor.authorAbrahão, Márcio [UNIFESP]
dc.contributor.authorDe Góis-Filho, J.f.
dc.contributor.authorBoffetta, P.
dc.contributor.authorWünsch-filho, V.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionRegistro de Câncer de Base Populacional de Goiânia Hospital Araújo Jorge
dc.contributor.institutionWorld Health Organization International Agency for Research on Cancer
dc.contributor.institutionHospital de Clínicas de Porto Alegre Departamento de Oncologia
dc.contributor.institutionHospital Heliópolis Departamento de Cirurgia de Cabeça e Pescoço
dc.contributor.institutionHospital do Câncer A.C. Camargo Departamento de Cirurgia de Cabeça e Pescoço
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionInstituto do Câncer Arnaldo Vieira de Carvalho Departamento de Cirurgia de Cabeça e Pescoço
dc.contributor.institutionMount Sinai School of Medicine The Tisch Cancer Institute
dc.contributor.institutionInternational Prevention Research Institute
dc.date.accessioned2015-06-14T13:43:17Z
dc.date.available2015-06-14T13:43:17Z
dc.date.issued2011-10-01
dc.description.abstractThe association of education, tobacco smoking, alcohol consumption, and interleukin-2 (IL-2 +114 and -384) and -6 (IL-6 -174) DNA polymorphisms with head and neck squamous cell carcinoma (HNSCC) was investigated in a cohort study of 445 subjects. IL-2 and IL-6 genotypes were determined by real-time PCR. Cox regression was used to estimate hazard ratios (HR) and 95% confidence intervals (95%CI) of disease-specific survival according to anatomical sites of the head and neck. Mean age was 56 years and most patients were males (87.6%). Subjects with 5 or more years of schooling had better survival in larynx cancer. Smoking had no effect on HNSCC survival, but alcohol consumption had a statistically significant effect on larynx cancer. IL-2 gene +114 G/T (HR = 0.52; 95%CI = 0.15-1.81) and T/T (HR = 0.22; 95%CI = 0.02-3.19) genotypes were associated with better survival in hypopharynx cancer. IL-2 +114 G/T was a predictor of poor survival in oral cavity/oropharynx cancer and larynx cancer (HR = 1.32; 95%CI = 0.61-2.85). IL-2 -384 G/T was associated with better survival in oral cavity/oropharynx cancer (HR = 0.80; 95%CI = 0.45-1.42) and hypopharynx cancer (HR = 0.68; 95%CI = 0.21-2.20), but an inverse relationship was observed for larynx cancer. IL-6 -174 G/C was associated with better survival in hypopharynx cancer (HR = 0.68; 95%CI = 0.26-1.78) and larynx cancer (HR = 0.93; 95%CI = 0.42-2.07), and C/C reduced mortality in larynx cancer. In general, our results are similar to previous reports on the value of education, smoking, alcohol consumption, and IL-2 and IL-6 genetic polymorphisms for the prognosis of HNSCC, but the risks due to these variables are small and estimates imprecise.en
dc.description.affiliationUniversidade de São Paulo Faculdade de Saúde Pública Departamento de Epidemiologia
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina de Ribeirão Preto Laboratório de Genética Molecular
dc.description.affiliationUniversidade de São Paulo Faculdade de Medicina Departamento de Medicina Preventiva
dc.description.affiliationRegistro de Câncer de Base Populacional de Goiânia Hospital Araújo Jorge
dc.description.affiliationWorld Health Organization International Agency for Research on Cancer
dc.description.affiliationHospital de Clínicas de Porto Alegre Departamento de Oncologia
dc.description.affiliationUniversidade de São Paulo Instituto de Medicina Tropical Laboratório de Virologia
dc.description.affiliationHospital Heliópolis Departamento de Cirurgia de Cabeça e Pescoço
dc.description.affiliationHospital do Câncer A.C. Camargo Departamento de Cirurgia de Cabeça e Pescoço
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Departamento de Otorrinolaringologia e Distúrbios da Comunicação
dc.description.affiliationInstituto do Câncer Arnaldo Vieira de Carvalho Departamento de Cirurgia de Cabeça e Pescoço
dc.description.affiliationMount Sinai School of Medicine The Tisch Cancer Institute
dc.description.affiliationInternational Prevention Research Institute
dc.description.affiliationUnifespUNIFESP, Depto. de Otorrinolaringologia e Distúrbios da Comunicação
dc.description.sourceSciELO
dc.format.extent1006-1012
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2011007500097
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 44, n. 10, p. 1006-1012, 2011.
dc.identifier.doi10.1590/S0100-879X2011007500097
dc.identifier.fileS0100-879X2011001000005.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2011001000005
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/6644
dc.identifier.wosWOS:000295721600005
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSmokingen
dc.subjectAlcoholen
dc.subjectInterleukinen
dc.subjectHead and neck canceren
dc.subjectCancer prognosisen
dc.subjectSurvival analysisen
dc.titleEducation, tobacco smoking, alcohol consumption, and IL-2 and IL-6 gene polymorphisms in the survival of head and neck canceren
dc.typeinfo:eu-repo/semantics/article
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