Inflammation in cancer cachexia: To resolve or not to resolve (is that the question?)

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dc.contributor.authorSeelaender, Marilia
dc.contributor.authorBatista Junior, Miguel
dc.contributor.authorLira, Fabio [UNIFESP]
dc.contributor.authorSilverio, Renata
dc.contributor.authorRossi-Fanelli, Filippo
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniv Mogi das Cruzes
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Roma La Sapienza
dc.date.accessioned2016-01-24T14:27:31Z
dc.date.available2016-01-24T14:27:31Z
dc.date.issued2012-08-01
dc.description.abstractBackground & aims: Cachexia is associated with poor prognosis and shortened survival in cancer patients. Growing evidence points out to the importance of chronic systemic inflammation in the aetiology of this syndrome. in the recent past, chronic inflammation was considered to result from overexpression and release of pro-inflammatory factors. However, this conception is now the focus of debate, since the importance of a crescent number of pro-resolving agents in the dissolution of inflammation is now recognised - leading to the hypothesis that chronic inflammation occurs rather due to failure in the resolution process. We intend to put forward the possibility that this may also be occurring in cancer cachexia.Methods: Recent reviews on inflammation and cachexia, and on the factors involved in the resolution of inflammation are discussed.Results: the available information suggests that indeed, inflammation resolution failure may be present in cachexia and therefore we speculate on possible mechanisms.Conclusions: We emphasise the importance of studying resolution-related mechanisms in cancer cachexia and propose the opening of a new venue for cachexia treatment. (C) 2012 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.en
dc.description.affiliationUniv São Paulo, Inst Biomed Sci, Canc Metab Res Grp, BR-05508900 São Paulo, Brazil
dc.description.affiliationUniv Mogi das Cruzes, Ctr Integrated Biotechnol, Lab Adipose Tissue Biol, Mogi Das Cruzes, Brazil
dc.description.affiliationUniversidade Federal de São Paulo UNIFESP, Dept Physiol, Div Nutr Physiol, São Paulo, Brazil
dc.description.affiliationUniv Roma La Sapienza, Dept Clin Med, Rome, Italy
dc.description.affiliationUnifespUniversidade Federal de São Paulo UNIFESP, Dept Physiol, Div Nutr Physiol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 08/54091-9
dc.description.sponsorshipIDFAPESP: 09/53510-0
dc.format.extent562-566
dc.identifierhttp://dx.doi.org/10.1016/j.clnu.2012.01.011
dc.identifier.citationClinical Nutrition. Edinburgh: Churchill Livingstone, v. 31, n. 4, p. 562-566, 2012.
dc.identifier.doi10.1016/j.clnu.2012.01.011
dc.identifier.issn0261-5614
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35132
dc.identifier.wosWOS:000307419800018
dc.language.isoeng
dc.publisherChurchill Livingstone
dc.relation.ispartofClinical Nutrition
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectCachexiaen
dc.subjectInflammationen
dc.subjectResolutionen
dc.subjectCanceren
dc.titleInflammation in cancer cachexia: To resolve or not to resolve (is that the question?)en
dc.typeinfo:eu-repo/semantics/article
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