Autonomic processing of the cardiovascular reflexes in the nucleus tractus solitarii

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dc.contributor.authorMachado, B. H.
dc.contributor.authorMauad, H.
dc.contributor.authorChianca, D. A.
dc.contributor.authorHaibara, A. S.
dc.contributor.authorColombari, Eduardo [UNIFESP]
dc.contributor.institutionUNIV FED ESPIRITO SANTO
dc.contributor.institutionUNIV FED OURO PRETO
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T16:24:00Z
dc.date.available2018-06-15T16:24:00Z
dc.date.issued1997-04-01
dc.description.abstractThe nucleus tractus solitarii (NTS) receives afferent projections from the arterial baroreceptors, carotid chemoreceptors and cardiopulmonary receptors and as a function of this information produces autonomic adjustments in order to maintain arterial blood pressure within a narrow range of variation. The activation of each of these cardiovascular afferents produces a specific autonomic response by the excitation of neuronal projections from the NTS to the ventrolateral areas of the medulla (nucleus ambiguus, caudal and rostral ventrolateral medulla). The neurotransmitters at the NTS level as well as the excitatory amino acid (EAA) receptors involved in the processing of the autonomic responses in the NTS, although extensively studied, remain to be completely elucidated, In the present review we discuss the role of the EAA L-glutamate and its different receptor subtypes in the processing of the cardiovascular reflexes in the NTS. The data presented in this review related to the neurotransmission in the NTS are based on experimental evidence obtained in our laboratory in unanesthetized rats. The two major conclusions of the present review are that a) the excitation of the cardiovagal component by cardiovascular reflex activation (chemo- and Bezold-Jarisch reflexes) or by L-glutamate microinjection into the NTS is mediated by N-methyl-D-aspartate (NMDA) receptors, and b) the sympatho-excitatory component of the chemoreflex and the presser response to L-glutamate microinjected into the NTS are not affected by an NMDA receptor antagonist, suggesting that the sympatho-excitatory component of these responses is mediated by non-NMDA receptors.en
dc.description.affiliationUNIV FED ESPIRITO SANTO,CTR BIOMED,DEPT CIENCIAS FISIOL,BR-29040090 VITORIA,ES,BRAZIL
dc.description.affiliationUNIV FED OURO PRETO,DEPT CIENCIAS BIOL,BR-35400000 OURO PRETO,MG,BRAZIL
dc.description.affiliationUNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT FISIOL,BR-04023060 SAO PAULO,SP,BRAZIL
dc.description.affiliationUnifespUNIV FED SAO PAULO,ESCOLA PAULISTA MED,DEPT FISIOL,BR-04023060 SAO PAULO,SP,BRAZIL
dc.description.sourceWeb of Science
dc.format.extent533-543
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1997000400015
dc.identifier.citationBrazilian Journal Of Medical And Biological Research. Sao Paulo: Assoc Bras Divulg Cientifica, v. 30, n. 4, p. 533-543, 1997.
dc.identifier.doi10.1590/S0100-879X1997000400015
dc.identifier.fileS0100-879X1997000400015.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X1997000400015
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43119
dc.identifier.wosWOS:A1997WT02000015
dc.language.isoeng
dc.publisherAssoc Bras Divulg Cientifica
dc.relation.ispartofBrazilian Journal Of Medical And Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectL-glutamateen
dc.subjectexcitatory amino acid receptorsen
dc.subjectNMDA receptorsen
dc.subjectbaroreflexen
dc.subjectchemoreflexen
dc.subjectBezold-Jarisch reflexen
dc.subjectAP-5en
dc.subjectkynureic aciden
dc.titleAutonomic processing of the cardiovascular reflexes in the nucleus tractus solitariien
dc.typeinfo:eu-repo/semantics/article
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