Lymphocyte proliferation stimulated by activated human macrophages treated with Canova

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dc.contributor.authorBurbano, Rommel Rodriguez
dc.contributor.authorLeal, Mariana Ferreira [UNIFESP]
dc.contributor.authorCosta, Joana Borges da
dc.contributor.authorBahia, Marcelo de Oliveira
dc.contributor.authorLima de Lima, Patricia Danielle
dc.contributor.authorKhayat, Andre Salim
dc.contributor.authorSeligman, Igor Chamon
dc.contributor.authorAssumpcao, Paulo Plmentel de
dc.contributor.authorBuchi, Dorly de Freitas
dc.contributor.authorCardoso Smith, Marilia de Arruda [UNIFESP]
dc.contributor.institutionFed Univ Para
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Fed Parana
dc.date.accessioned2016-01-24T13:52:03Z
dc.date.available2016-01-24T13:52:03Z
dc.date.issued2009-01-01
dc.description.abstractIntroduction: Canova (CA) is a homeopathic medication with immunomodulatory properties, recommended for patients with a depressed immune system. CA has been reported to increase in leukocyte numbers, cellular differentiation and reduction in tumor size.Aim and method. Since CA may stimulate lymphocyte differentiation, proliferation, and/or survival, the aim of the present study was to compare the mitotic index (MI) of phytohemagglutinin-stimulated human lymphocytes cultured in a medium supplemented with human macrophages activated by CA, with lymphocytes cultured in a medium without CA-treated macrophages.Results: in this study, the MI of lymphocyte cultured received the medium containing CA-stimulated macrophages showed a higher proliferation index (p < 0.01) than the lymphocytes cultured in a medium without CA-treated macrophages. Our results suggest that CA treatment, in addition to activating macrophages, indirectly induces lymphocyte proliferation and has potential as a new adjuvant therapeutic approach. Homeopathy (2009) 98, 45-48.en
dc.description.affiliationFed Univ Para, Dept Biol, Lab Citogenet Humana, Ctr Ciencias Biol,Inst Ciencias Biol, BR-66075900 Belem, Para, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Disciplina Genet, São Paulo, Brazil
dc.description.affiliationFed Univ Para, Hosp Joao de Barros Barreto, BR-66075900 Belem, Para, Brazil
dc.description.affiliationUniv Fed Parana, Setor Ciencias Biol, BR-80060000 Curitiba, Parana, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Disciplina Genet, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFinanciadora de Estudos e Projetos (FINEP CT-INFRA/FADESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipFundacao de Amparo e Desenvolvimento da Pesquisa (FADESP)
dc.description.sponsorshipPQ-2
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipIDFinanciadora de Estudos e Projetos (FINEP CT-INFRA/FADESP): 0927-03
dc.description.sponsorshipIDCNPq: 308256/2006-9
dc.format.extent45-48
dc.identifierhttp://dx.doi.org/10.1016/j.homp.2008.11.011
dc.identifier.citationHomeopathy. Oxford: Elsevier B.V., v. 98, n. 1, p. 45-48, 2009.
dc.identifier.doi10.1016/j.homp.2008.11.011
dc.identifier.issn1475-4916
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31163
dc.identifier.wosWOS:000262829600008
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofHomeopathy
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectCanovaen
dc.subjectActivated macrophagesen
dc.subjectLymphocyte proliferationen
dc.subjectMitotic indexen
dc.subjectHomeopathyen
dc.titleLymphocyte proliferation stimulated by activated human macrophages treated with Canovaen
dc.typeinfo:eu-repo/semantics/article
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