Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients

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dc.contributor.authorYamashita, Eliana K.
dc.contributor.authorTeixeira, Bianca M.
dc.contributor.authorYoshihara, Renata N.
dc.contributor.authorKuniyoshi, Renata K.
dc.contributor.authorAlves, Beatriz C. A.
dc.contributor.authorGehrke, Flavia S.
dc.contributor.authorVilas-Boas, Viviane A.
dc.contributor.authorCorreia, Joao A.
dc.contributor.authorAzzalis, Ligia A. [UNIFESP]
dc.contributor.authorJunqueira, Virginia B. C. [UNIFESP]
dc.contributor.authorPereira, Edimar Cristiano [UNIFESP]
dc.contributor.authorFonseca, Fernando L. A. [UNIFESP]
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:35:21Z
dc.date.available2016-01-24T14:35:21Z
dc.date.issued2014-03-01
dc.description.abstractBackgroundHyperhomocysteinemia in breast cancer (BC) patients can be a risk factor for thromboembolic events. This study aimed to evaluate homocysteine and its cofators (folic acid and vitamin B12) concentrations and platelet count at diagnosis of BC, 3 and 6 months after the beginning of chemotherapy treatment and to correlate them with clinical data.MethodsThirty-five BC patients were included; blood samples were obtained by venipuncture. Plasmatic Hcy and cofactors concentrations were measured by competitive chemiluminescent enzyme immunoassay method. Platelet count was done using an automated analyzer. Statistical analysis was performed using the software SPSS.ResultsDuring chemotherapy, homocysteine (P = 0.032) and vitamin B12 (P < 0.001) concentrations increased, while folate and platelets decreased (P < 0.001). Among the clinical data, the menopausal status showed significant positive correlation (P = 0.022) with homocysteine concentration increase.ConclusionsEvaluation of homocysteine concentrations during chemotherapy is extremely important because their levels increase during chemotherapy treatment, thus increasing the risk of thromboembolism development.en
dc.description.affiliationABC, Sch Med, Dept Hematol & Oncol, Santo Andre, SP, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biol Sci, BR-09972270 Diadema, SP, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biol Sci, BR-09972270 Diadema, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2009/54343-0 2009/54342-4
dc.format.extent157-162
dc.identifierhttp://dx.doi.org/10.1002/jcla.21660
dc.identifier.citationJournal of Clinical Laboratory Analysis. Hoboken: John Wiley & Sons Inc, v. 28, n. 2, p. 157-162, 2014.
dc.identifier.doi10.1002/jcla.21660
dc.identifier.issn0887-8013
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/37473
dc.identifier.wosWOS:000332840500013
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Clinical Laboratory Analysis
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjecthomocysteineen
dc.subjectfolic aciden
dc.subjectvitamin B 12en
dc.subjectbreast neoplasmsen
dc.subjectchemotherapy and thromboembolismen
dc.titleSystemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patientsen
dc.typeinfo:eu-repo/semantics/article
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