Self-perception of knowledge and adherence reflecting the effectiveness of antiretroviral therapy

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dc.contributor.authorDagli-Hernandez, Carolina
dc.contributor.authorLucchetta, Rosa Camila
dc.contributor.authorde Nadai, Tales Rubens
dc.contributor.authorFernandez Galduroz, Jose Carlos [UNIFESP]
dc.contributor.authorMastroianni, Patricia de Carvalho
dc.date.accessioned2019-01-21T10:29:49Z
dc.date.available2019-01-21T10:29:49Z
dc.date.issued2016
dc.description.abstractObjectives: To evaluate which indirect method for assessing adherence best reflects highly active antiretroviral therapy (HAART) effectiveness and the factors related to adherence. Method: This descriptive, cross-sectional study was performed in 2012 at a reference center of the state of Sao Paulo. Self-report (simplified medication adherence questionnaire [SMAQ]) and drug refill parameters were compared to the viral load (clinical parameter of the effectiveness of pharmacotherapy [EP]) to evaluate the EP. The "Cuestionario para la Evaluacion de la Adhesion al Tratamiento Antiretroviral" (CEAT-VIH) was used to evaluate factors related to adherence and the EP and, complementarily, patient self-perception of adherence was compared to the clinical parameter of the EP. Results: Seventy-five patients were interviewed, 60 of whom were considered as adherent from the clinical parameter of the EP and ten were considered as adherent from all parameters. Patient self-perception about adherence was the instrument that best reflected the EP when compared to the standardized self-report questionnaire (SMAQ) and drug refill parameter. The level of education and the level of knowledge on HAART were positively correlated to the EP. Forgetfulness, alcohol use, and lack of knowledge about the medications were the factors most frequently reported as a cause of nonadherence. Conclusion: A new parameter of patient self-perception of adherence, which is a noninvasive, inexpensive instrument, could be applied and assessed as easily as self-report (SMAQ) during monthly drug refill, since it allows monitoring adherence through pharmaceutical assistance. Therefore, patient adherence to HAART could be evaluated using self-perception (CEAT-VIH) and the viral load test.en
dc.description.affiliationDepartment of Drugs and Medications, School of Pharmaceutical Sciences of the UNESP – Univ Estadual Paulista, Araraquara
dc.description.affiliationDepartment of Surgery and Anatomy, Americo Brasiliense State Hospital
dc.description.affiliationDepartment of Psychobiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.affiliationUnifespDepartment of Psychobiology, Universidade Federal de São Paulo (UNIFESP), São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipProgram of Support to Scientific Development of the School of Pharmaceutical Sciences at the Universidade Estadual Paulista - UNESP [2010/21-I]
dc.description.sponsorshipFAPESP [2014/03468-6]
dc.description.sponsorshipIDProgram of Support to Scientific Development of the School of Pharmaceutical Sciences at the Universidade Estadual Paulista - UNESP: 2010/21-I
dc.description.sponsorshipIDFAPESP: 2014/03468-6
dc.format.extent1787-1793
dc.identifierhttps://doi.org/10.2147/PPA.S112108
dc.identifier.citationPatient Preference And Adherence. Albany, v. 10, p. 1787-1793, 2016.
dc.identifier.doi10.2147/PPA.S112108
dc.identifier.fileWOS000383153700006.pdf
dc.identifier.issn1177-889X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/49414
dc.identifier.wosWOS:000383153700006
dc.language.isoeng
dc.publisherBrazilian Soc Urol
dc.relation.ispartofPatient Preference And Adherence
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectHealth Literacyen
dc.subjectAnti-Hiv Agentsen
dc.subjectPatient Complianceen
dc.subjectAntiretroviral Therapyen
dc.subjectHighly Activeen
dc.subjectAcquired Immunodeficiency SyndromeHiv-Infected Patientsen
dc.subjectLess-Than 95-Percenten
dc.subjectMedication Adherenceen
dc.subjectBrazilen
dc.subjectCareen
dc.subjectQuestionnaireen
dc.subjectSuppressionen
dc.subjectChallengesen
dc.subjectLiteracyen
dc.subjectHiv/Aidsen
dc.titleSelf-perception of knowledge and adherence reflecting the effectiveness of antiretroviral therapyen
dc.typeinfo:eu-repo/semantics/article
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