Post-transplant anti-HLA class II antibodies as risk factor for late kidney allograft failure

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dc.contributor.authorCampos, E. F.
dc.contributor.authorTedesco-Silva, H.
dc.contributor.authorMachado, P. G.
dc.contributor.authorFranco, M.
dc.contributor.authorMedina-Pestana, J. O.
dc.contributor.authorGerbase-DeLima, Maria [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:41:29Z
dc.date.available2016-01-24T12:41:29Z
dc.date.issued2006-10-01
dc.description.abstractThe purpose of this study was to prospectively analyze the relationship between the post-transplant anti-HLA class I and/or class II panel reactive antibodies and graft failure due to chronic allograft nephropathy (CAN). We studied 512 first kidney recipients transplanted at a single center, with a graft functioning for at least 3 years. A single blood sample was collected from each patient for antibody evaluation. the median posttransplant time after blood collection was 4.4 years and did not differ between patients with (n = 91) or without anti-HLA antibodies (n = 421). Female gender, pregnancies and blood transfusions were associated with the presence of anti-HLA class I antibodies. Graft function deterioration was associated with anti-HLA class II antibodies. Multivariate analysis showed independent association for creatinine levels (RR = 7.5), acute rejection (RR = 2.6), recipient male gender (RR = 3.6) and anti-HLA class II antibodies (RR = 2.9) and CAN-associated graft loss. in conclusion, the presence of anti-HLA class II antibodies conferred a risk for graft loss before a decline in renal function and increased the risk of graft failure in patients who already had a decline in graft function. Thus, anti-HLA class II antibody monitoring is a useful tool for the management of long-term kidney recipients.en
dc.description.affiliationUniversidade Federal de São Paulo, Escola Paulista Med, Dept Pediat, Div Immunogenet, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Hosp Rim & Hipertensao, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Escola Paulista Med, Dept Pediat, Div Immunogenet, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Hosp Rim & Hipertensao, Div Nephrol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pathol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent2316-2320
dc.identifierhttp://dx.doi.org/10.1111/j.1600-6143.2006.01503.x
dc.identifier.citationAmerican Journal of Transplantation. Oxford: Blackwell Publishing, v. 6, n. 10, p. 2316-2320, 2006.
dc.identifier.doi10.1111/j.1600-6143.2006.01503.x
dc.identifier.issn1600-6135
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/29168
dc.identifier.wosWOS:000240366000012
dc.language.isoeng
dc.publisherBlackwell Publishing
dc.relation.ispartofAmerican Journal of Transplantation
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectanti-HLA antibodiesen
dc.subjectCANen
dc.subjectchronic allograft nephropathyen
dc.subjectcreatinineen
dc.subjecthumoral responseen
dc.subjectkidney graft failureen
dc.titlePost-transplant anti-HLA class II antibodies as risk factor for late kidney allograft failureen
dc.typeinfo:eu-repo/semantics/article
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