Angiogenesis and growth factor modulation induced by altelnagin C, a snake venom disintegrin-like, cysteine-rich protein on a rat skin wound model

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dc.contributor.authorCorreia St Ana, Estela Maria
dc.contributor.authorCacao Paiva Gouvea, Cibele Marli
dc.contributor.authorNakaie, Clovis Ryuichi [UNIFESP]
dc.contributor.authorSelistre-de-Araujo, Heloisa Sobreiro
dc.contributor.institutionUniversidade Federal de São Carlos (UFSCar)
dc.contributor.institutionUniv Fed Alfenas
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T13:51:50Z
dc.date.available2016-01-24T13:51:50Z
dc.date.issued2008-11-01
dc.description.abstractIn this work, we show that alternagin-C (ALT-C) and ALT-C PEP, a peptide derived from its sequence, were able to induce angiogenesis ill Wounded rat skin. A spherical Cutaneous excision was made in the back of each animal and treated with three different concentrations of ALT-C or ALT-C PEP. After that, the skin was removed and analyzed to verify the presence of new vessels and the expression of growth factors. ALT-C and ALT-C PEP induced the formation of new vessels and modulated the expression of growth factors, mainly VEGF and FGH. the expression of VEGF increased and it Could be detected Up to 7 days after injury. FGH also significantly increased, but at a lesser extent than VEGF. in conclusion, the present Study shows for the first time the stimulation of angiogenesis in an injured tissue by a disintegrin-like protein and that ALT-C may exert this effect by modulating the expression of growth factors.(c) 2008 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed Sao Carlos, Dept Ciencias Fisiol, BR-13565905 Sao Carlos, SP, Brazil
dc.description.affiliationUniv Fed Alfenas, Dept Ciencias Biol, BR-37130000 Alfenas, MG, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biofis, BR-04044020 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biofis, BR-04044020 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent20-27
dc.identifierhttp://dx.doi.org/10.1016/j.abb.2008.07.030
dc.identifier.citationArchives of Biochemistry and Biophysics. New York: Elsevier B.V., v. 479, n. 1, p. 20-27, 2008.
dc.identifier.doi10.1016/j.abb.2008.07.030
dc.identifier.issn0003-9861
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/30998
dc.identifier.wosWOS:000260593400003
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofArchives of Biochemistry and Biophysics
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectDisintegrinen
dc.subjectSnake venomen
dc.subjectGrowth factorsen
dc.subjectAlternagin-Cen
dc.subjectAlpha2betal integrinen
dc.subjectBothrops alternatusen
dc.subjectAngiogenesisen
dc.subjectSkin wounden
dc.subjectRat modelen
dc.subjectALT-C PEPen
dc.subjectPeptideen
dc.titleAngiogenesis and growth factor modulation induced by altelnagin C, a snake venom disintegrin-like, cysteine-rich protein on a rat skin wound modelen
dc.typeinfo:eu-repo/semantics/article
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