Texture Image Analysis in Differentiating Malignant from Benign Adrenal Cortical Tumors in Children and Adults

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dc.contributor.authorShirata, N. K.
dc.contributor.authorSredni, S. T.
dc.contributor.authorCastelo, A. [UNIFESP]
dc.contributor.authorSantinelli, A.
dc.contributor.authorMendonca, B.
dc.contributor.authorMontironi, R.
dc.contributor.authorLongatto Filho, A.
dc.contributor.authorZerbini, M. C. N.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionAdolfo Lutz Inst
dc.contributor.institutionNorthwestern Univ
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionPostdoctoral Fellowship Univ Minho
dc.date.accessioned2018-06-15T13:50:15Z
dc.date.available2018-06-15T13:50:15Z
dc.date.issued2009-08-01
dc.description.abstractObjective: To investigate the possible role of chromatin texture parameters, nuclear morphology, DNA ploidy and clinical functional status in discriminating benign from malignant adrenocortical tumors (ACT). Patients and Methods: Forty-eight cases of clinically benign (n=40) and clinically malignant (n=8) ACT with a minimum of 5-years' follow-up were evaluated for chromatin texture parameters (run length, standard deviation, configurable run length, valley, slope, peak and other 21 Markovian features that describe the distribution of the chromatin in the nucleus), nuclear morphology (nuclear area, nuclear perimeter, nuclear maximum and minumum diameter, nuclear shape), and DNA ploidy. Nuclear parameters were evaluated in Feulgen-stained 5 mu m paraffin-sections analyzed using a CAS 200 image analyzer. Results: Since ACTs present different biological features in children and adults, patients were divided into two groups: children (<= 15 years) and adults (>15 years). In the group of children DNA ploidy presented a marginal significance (p=0.05) in discriminating ACTs. None of the parameters discriminated between malignant and benign ACT in the adult group. Conclusion: ACTs are uncommon and definitive predictive criteria for malignancy remain uncertain, particularly in children. Our data point to DNA content evaluated by image analysis as a new candidate tool for this challenging task. Texture image analysis did not help to differentiate malignant from benign adrenal cortical tumors in children and adults.en
dc.description.affiliationUniv Sao Paulo, Dept Pathol, Fac Med, Sch Med, BR-05415070 Sao Paulo, Brazil
dc.description.affiliationAdolfo Lutz Inst, Div Pathol, Sao Paulo, Brazil
dc.description.affiliationNorthwestern Univ, Feimberg Sch Med, Childrens Mem Res Ctr, Canc Biol & Epigenom Program, Chicago, IL USA
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Div Infect Dis, Sao Paulo, Brazil
dc.description.affiliationUniv Sao Paulo, Clin Hosp, Dept Clin Med, BR-05415070 Sao Paulo, Brazil
dc.description.affiliationPostdoctoral Fellowship Univ Minho, Sch Hlth Sci, Braga, Portugal
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP, Div Infect Dis, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent3365-3368
dc.identifierhttp://ar.iiarjournals.org/content/29/8/3365.long
dc.identifier.citationAnticancer Research. Athens: Int Inst Anticancer Research, v. 29, n. 8, p. 3365-3368, 2009.
dc.identifier.issn0250-7005
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/42596
dc.identifier.wosWOS:000268846800068
dc.language.isoeng
dc.publisherInt Inst Anticancer Research
dc.relation.ispartofAnticancer Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdrenocortical tumorsen
dc.subjectadrenalen
dc.subjectimage analysisen
dc.subjectchromatin textureen
dc.subjectnuclear morphologyen
dc.subjectDNA ploidyen
dc.subjectChildrenen
dc.subjectadultsen
dc.titleTexture Image Analysis in Differentiating Malignant from Benign Adrenal Cortical Tumors in Children and Adultsen
dc.typeinfo:eu-repo/semantics/article
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