How useful is preoperative imaging for tumor, node, metastasis (TNM) staging of gastric cancer? A meta-analysis

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dc.contributor.authorSeevaratnam, Rajini
dc.contributor.authorCardoso, Roberta
dc.contributor.authorMcgregor, Caitlin
dc.contributor.authorLourenço, Laércio Gomes [UNIFESP]
dc.contributor.authorMahar, Alyson
dc.contributor.authorSutradhar, Rinku
dc.contributor.authorLaw, Calvin
dc.contributor.authorPaszat, Lawrence
dc.contributor.authorCoburn, Natalie
dc.contributor.institutionSunnybrook Hlth Sci Ctr
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionQueens Univ
dc.contributor.institutionUniv Toronto
dc.contributor.institutionInst Clin Evaluat Sci
dc.date.accessioned2016-01-24T14:27:37Z
dc.date.available2016-01-24T14:27:37Z
dc.date.issued2012-09-01
dc.description.abstractBackground Surgery is the fundamental curative option for gastric cancer patients. Imaging scans are routinely prescribed in an attempt to stage the disease prior to surgery. Consequently, the correlation between radiology exams and pathology is crucial for appropriate treatment planning.Methods Systematic searches were conducted using Medline, Embase, and the Cochrane Central Register of Controlled Trials from January 1, 1998 to December 1, 2009. We calculated the accuracy, overstaging rate, understaging rate, Kappa statistic, sensitivity, and specificity for abdominal ultrasound (AUS), computed tomography (CT), magnetic resonance imaging (MRI), and positron emission tomography (PET) with respect to the gold standard (pathology). We also compared the performance of CT by detector number and image type. A meta-analysis was performed.Results for pre-operative T staging MRI scans had better performance accuracy than CT and AUS; CT scanners using >= 4 detectors and multi-planar reformatted (MPR) images had higher staging performances than scanners with <4 detectors and axial images only. for pre-operative N staging PET had the lowest sensitivity, but the highest specificity among modalities; CT performance did not significantly differ by detector number or addition of MPR images. for pre-operative M staging performance did not significantly differ by modality, detector number, or MPR images.Conclusions the agreement between pre-operative TNM staging by imaging scans and post-operative staging by pathology is not perfect and may affect treatment decisions. Operator dependence and heterogeneity of data may account for the variations in staging performance. Physicians should consider this discrepancy when creating their treatment plans.en
dc.description.affiliationSunnybrook Hlth Sci Ctr, Sunnybrook Res Inst, Toronto, ON M4N 3M5, Canada
dc.description.affiliationSunnybrook Hlth Sci Ctr, Dept Med Imaging, Toronto, ON M4N 3M5, Canada
dc.description.affiliationUniversidade Federal de São Paulo, Dept Surg, São Paulo, Brazil
dc.description.affiliationQueens Univ, Dept Community Hlth & Epidemiol, Kingston, ON, Canada
dc.description.affiliationUniv Toronto, Div Biostat, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada
dc.description.affiliationInst Clin Evaluat Sci, Toronto, ON, Canada
dc.description.affiliationSunnybrook Hlth Sci Ctr, Div Surg Oncol, Odette Canc Ctr, Toronto, ON M4N 3M5, Canada
dc.description.affiliationUniv Toronto, Dept Hlth Policy Management & Evaluat, Toronto, ON, Canada
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Surg, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCanadian Cancer Society
dc.description.sponsorshipOntario Ministry of Health and Long-Term Care
dc.description.sponsorshipHanna Family Chair in Surgical Oncology
dc.description.sponsorshipIDCanadian Cancer Society: 019325
dc.format.extentS3-S18
dc.identifierhttp://dx.doi.org/10.1007/s10120-011-0069-6
dc.identifier.citationGastric Cancer. New York: Springer, v. 15, p. S3-S18, 2012.
dc.identifier.doi10.1007/s10120-011-0069-6
dc.identifier.issn1436-3291
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35208
dc.identifier.wosWOS:000313419000003
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofGastric Cancer
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectAbdominal ultrasound (AUS)en
dc.subjectComputed tomography (CT)en
dc.subjectMagnetic resonance imaging (MRI)en
dc.subjectPositron emission tomography (PET)en
dc.subjectGastric canceren
dc.titleHow useful is preoperative imaging for tumor, node, metastasis (TNM) staging of gastric cancer? A meta-analysisen
dc.typeinfo:eu-repo/semantics/article
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