Sleep deprivation impairs emotional memory retrieval in mice: Influence of sex

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dc.contributor.authorFernandes-Santos, Luciano [UNIFESP]
dc.contributor.authorPatti, Camilla de Lima [UNIFESP]
dc.contributor.authorZanin, Karina Agustini [UNIFESP]
dc.contributor.authorFernandes, Helaine Arrais [UNIFESP]
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorAndersen, Monica Levy [UNIFESP]
dc.contributor.authorFrussa-Filho, Roberto [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:27:33Z
dc.date.available2016-01-24T14:27:33Z
dc.date.issued2012-08-07
dc.description.abstractThe deleterious effects of paradoxical sleep deprivation on memory processes are well documented. However, non-selective sleep deprivation occurs more commonly in modern society and thus represents a better translational model. We have recently reported that acute total sleep deprivation (TSD) for 6 h immediately before testing impaired performance of male mice in the plus-maze discriminative avoidance task (PM-DAT) and in the passive avoidance task (PAT). in order to extend these findings to females, we examined the effect of (pre-test) TSD on the retrieval of different memory tasks in both male and female mice. Animals were tested using 3 distinct memory models: 1) conditioning fear context (CFC), 2) PAT and 3) PM-DAT. in all experiments, animals were totally sleep-deprived by the gentle interference method for 6 h immediately before being tested. in the CFC task and the PAT, TSD induced memory impairment regardless of sex. in PM-DAT, the memory impairing effects of TSD were greater in females. Collectively, our results confirm the impairing effect of TSD on emotional memory retrieval and demonstrate that it can be higher in female mice depending on the memory task evaluated. (C) 2012 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Farmacol, BR-04023062 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psicobiol, BR-04023062 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipAssociacao Fundo de Pesquisa Pesquisa (AFIP)
dc.description.sponsorshipIDFAPESP: 1998/14303-3
dc.format.extent216-222
dc.identifierhttp://dx.doi.org/10.1016/j.pnpbp.2012.03.014
dc.identifier.citationProgress in Neuro-psychopharmacology & Biological Psychiatry. Oxford: Pergamon-Elsevier B.V., v. 38, n. 2, p. 216-222, 2012.
dc.identifier.doi10.1016/j.pnpbp.2012.03.014
dc.identifier.fileWOS000307258300016.pdf
dc.identifier.issn0278-5846
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/35168
dc.identifier.wosWOS:000307258300016
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofProgress in Neuro-psychopharmacology & Biological Psychiatry
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectConditioning fear contexten
dc.subjectGenderen
dc.subjectMemory retrievalen
dc.subjectPassive avoidance tasken
dc.subjectPlus-maze discriminative avoidance tasken
dc.subjectSleep deprivationen
dc.titleSleep deprivation impairs emotional memory retrieval in mice: Influence of sexen
dc.typeinfo:eu-repo/semantics/article
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