Mobius sequence in children exposed in utero to misoprostol: Neuropathological study of three cases

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dc.contributor.authorMarques-Dias, M. J.
dc.contributor.authorGonzalez, C. H.
dc.contributor.authorRosemberg, S.
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:34:08Z
dc.date.available2016-01-24T12:34:08Z
dc.date.issued2003-12-01
dc.description.abstractBACKGROUND: Misoprostol exposure in the first trimester of pregnancy has been related to congenital malformations, particularly the Mobius sequence and terminal transverse limb defects. CASES: Neuropathological findings of three patients with Mobius sequence related to misoprostol are reported. No previous pathological studies have shown these abnormalities to be associated with misoprostol exposure in utero. the brain stem was cut serially, from the rostral mesencephalum to,the caudal aspect of the medulla, and all fragments were stained with hematoxylin-eosin and cresyl violet. Old ischemic-anoxic foci of gliosis, with necrosis and calcification, dorsally situated, were present from the pons to the medulla, involving some cranial nerve nuclei (especially the IV, VII and XII) that were partially or completely depopulated of neural cells. CONCLUSIONS: the findings suggest a circulatory mechanism to the Mobius sequence, with vascular disruption involving the territory of the subdavian artery, occurring in a critical period of embryonic life between six to eight weeks postconception. These cases add further evidence of the role of misoprostol as a teratogen. (C) 2003 Wiley-Liss, Inc.en
dc.description.affiliationUniv São Paulo, Fac Med, Dept Neurol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Dept Pediat, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Inst Biosci, Dept Biol, São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Fac Med, Dept Pathol, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1002-1007
dc.identifierhttp://dx.doi.org/10.1002/bdra.10144
dc.identifier.citationBirth Defects Research Part A-clinical and Molecular Teratology. New York: Wiley-liss, v. 67, n. 12, p. 1002-1007, 2003.
dc.identifier.doi10.1002/bdra.10144
dc.identifier.issn1542-0752
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/27490
dc.identifier.wosWOS:000187445400011
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofBirth Defects Research Part A-clinical and Molecular Teratology
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectMobius sequenceen
dc.subjectmisoprostolen
dc.subjectvascular disruptionen
dc.subjectprenatal brain stem ischemiaen
dc.titleMobius sequence in children exposed in utero to misoprostol: Neuropathological study of three casesen
dc.typeinfo:eu-repo/semantics/article
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