Effect of High- and Low-Frequency Transcutaneous Electrical Nerve Stimulation on Angiogenesis and Myofibroblast Proliferation in Acute Excisional Wounds in Rat Skin

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dc.citation.issue8
dc.citation.volume29
dc.contributor.authorMachado, Aline F. P. [UNIFESP]
dc.contributor.authorLiebano, Richard E. [UNIFESP]
dc.contributor.authorFurtado, Fabianne [UNIFESP]
dc.contributor.authorHochman, Bernardo [UNIFESP]
dc.contributor.authorFerreira, Lydia M. [UNIFESP]
dc.coveragePhiladelphia
dc.date.accessioned2020-08-14T13:44:02Z
dc.date.available2020-08-14T13:44:02Z
dc.date.issued2016
dc.description.abstractOBJECTIVE: This study evaluated the effects of high- (HF) and low-frequency (LF) transcutaneous electrical nerve stimulation on angiogenesis and myofibroblast proliferation in acute excisional wounds in rat skin. DESIGN: This was an experimental controlled and randomized study. PARTICIPANTS: An excisional wound was made on the back of 90 adult male EPM1-Wistar rats using an 8-mm punch. INTERVENTIONS: The animals were randomly assigned to the HF group (80 Hz), LF group (5 Hz), or control group. Transcutaneous electrical nerve stimulation (pulse duration, 200 microsecondsen
dc.description.abstractcurrent amplitude, 15 mA) was delivered (session length, 60 minutes) on 3 consecutive days. MEAN OUTCOME MEASURE: Immunohistochemistry was performed on postoperative days 3, 7, and 14 for counting blood vessels and myofibroblasts. MEAN OUTCOME RESULTS: The LF group had significantly more blood vessels than the HF group on day 3 (P = .004). The HF group had significantly less blood vessels than did the control group on days 7 (P = .002) and 14 (P = .034) and less myofibroblasts than did both the LF and control groups on day 3 (P = .004) and less than did the control group on day 7 (P = .001). CONCLUSION: There seems to be a benefit to the use of LF transcutaneous electrical nerve stimulation in the healing of acute excisional wounds, but further studies are warranted.en
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Div Plast Surg, Sao Paulo, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP, Div Plast Surg, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent357-363
dc.identifierhttp://dx.doi.org/10.1097/01.ASW.0000488721.83423.f3
dc.identifier.citationAdvances In Skin & Wound Care. Philadelphia, v. 29, n. 8, p. 357-363, 2016.
dc.identifier.doi10.1097/01.ASW.0000488721.83423.f3
dc.identifier.issn1527-7941
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57492
dc.identifier.wosWOS:000380631100005
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofAdvances In Skin & Wound Care
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjecttranscutaneous electric nerve stimulationen
dc.subjectwound healingen
dc.subjectangiogenesisen
dc.subjectmyofibroblast proliferationen
dc.titleEffect of High- and Low-Frequency Transcutaneous Electrical Nerve Stimulation on Angiogenesis and Myofibroblast Proliferation in Acute Excisional Wounds in Rat Skinen
dc.typeinfo:eu-repo/semantics/article
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