Genetically altered animals in the study of the metabolic functions of peptide hormone systems

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dc.contributor.authorMori, Marcelo Alves da Silva [UNIFESP]
dc.contributor.authorBader, Michael [UNIFESP]
dc.contributor.authorPesquero, João Bosco [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionMax Delbruck Ctr Mol Med
dc.date.accessioned2018-06-15T17:05:14Z
dc.date.available2018-06-15T17:05:14Z
dc.date.issued2008-01-01
dc.description.abstractPurpose of reviewHere we review the use of genetically altered animals to address the roles of peptide hormone systems in the modulation of energy homeostasis. Despite the disseminated use of transgenic techniques to establish the functional relevance of several peptide hormone systems, we focus on two multifunctional systems, the renin-angiotensin and the kallikrein-kinin systems. Initially, we explored the background information supporting the functional aspects of these systems, followed by novel knowledge obtained with the phenotypic characterization of genetically altered animals.Recent findingsA role for the renin-angiotensin system in the regulation of adiposity and glucose metabolism has been suggested. Studies using genetically altered animals not only confirmed the physiological relevance of angiotensin 11 in the control of energy homeostasis, but also revealed that the adipose tissue renin-angiotensin system participates in the endocrine modulation of cardiovascular and renal function. On the other hand, the involvement of the kallikrein-kinin system with metabolic processes was not so obvious. Recent reports using genetically altered animals, however, provided strong evidence to support an important role for kinins in the control of glucose homeostasis and energy balance.SummaryHere we present examples of how genetically altered animals contribute to a final postulation of the physiological roles of certain hormone systems, bringing new insights into the field.en
dc.description.affiliationUniv Fed Sao Paulo, Dept Biofis, BR-04023062 Sao Paulo, Brazil
dc.description.affiliationMax Delbruck Ctr Mol Med, Berlin, Germany
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Biofis, BR-04023062 Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent11-17
dc.identifierhttp://dx.doi.org/10.1097/MNH.0b013e3282f2909a
dc.identifier.citationCurrent Opinion In Nephrology And Hypertension. Philadelphia: Lippincott Williams & Wilkins, v. 17, n. 1, p. 11-17, 2008.
dc.identifier.doi10.1097/MNH.0b013e3282f2909a
dc.identifier.issn1062-4821
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43460
dc.identifier.wosWOS:000253336700002
dc.language.isoeng
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofCurrent Opinion In Nephrology And Hypertension
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectkallikrein-kinin systemen
dc.subjectknockout miceen
dc.subjectpeptide hormonesen
dc.subjectrenin-angiotensin systemen
dc.subjecttransgenicen
dc.titleGenetically altered animals in the study of the metabolic functions of peptide hormone systemsen
dc.typeinfo:eu-repo/semantics/article
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