Schizophrenia and chromosome 6p

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dc.contributor.authorTurecki, Gustavo
dc.contributor.authorRouleau, Guy A.
dc.contributor.authorJoober, Ridha
dc.contributor.authorMari, Jair de Jesus [UNIFESP]
dc.contributor.authorMorgan, Kenneth
dc.contributor.institutionMCGILL UNIV
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T12:30:20Z
dc.date.available2016-01-24T12:30:20Z
dc.date.issued1997-04-18
dc.description.abstractSeveral studies have recently reported genetic linkage between markers located on the short arm of chromosome 6 and schizophrenia, Valid conclusions, however, are difficult to formulate because chromosomal markers that yielded positive results span a relatively large region of chromosome 6, and studies did not necessarily obtain consistent results with regard to the particular loci tested, Here, we report a meta-analysis of the results of linkage studies of schizophrenia that used chromosome 6p markers. After conducting a systematic search, nine different studies mere selected for the analysis using defined criteria, Pooled P values were obtained for all common markers investigated and provided additional support for a major susceptibility locus for schizophrenia in this region. in addition, two markers located 2 cM apart, D6S274 and D6S285, provided the most significant results, These findings may help narrow the chromosomal region in the search for a major gene implicated in schizophrenia, (C) 1997 Wiley-Lies, Inc.en
dc.description.affiliationMCGILL UNIV, CTR RES NEUROSCI, DEPT NEUROL & NEUROSCI, MONTREAL, PQ H3A 2T5, CANADA
dc.description.affiliationMCGILL UNIV, DEPT HUMAN GENET, MONTREAL, PQ, CANADA
dc.description.affiliationMCGILL UNIV, DEPT MED, MONTREAL, PQ, CANADA
dc.description.affiliationESCOLA PAULISTA MED, DEPT PSIQUIAT, BR-04023 São Paulo, BRAZIL
dc.description.affiliationUnifespESCOLA PAULISTA MED, DEPT PSIQUIAT, BR-04023 São Paulo, BRAZIL
dc.description.sourceWeb of Science
dc.format.extent195-198
dc.identifierhttp://dx.doi.org/10.1002/(SICI)1096-8628(19970418)74:2<195
dc.identifier.citationAmerican Journal of Medical Genetics. New York: Wiley-liss, v. 74, n. 2, p. 195-198, 1997.
dc.identifier.doi10.1002/(SICI)1096-8628(19970418)74:2<195
dc.identifier.issn0148-7299
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/25715
dc.identifier.wosWOS:A1997WV79700016
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofAmerican Journal of Medical Genetics
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectpsychiatric disorderen
dc.subjectlinkage analysisen
dc.subjectmeta-analysisen
dc.titleSchizophrenia and chromosome 6pen
dc.typeinfo:eu-repo/semantics/article
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