Inflammatory Mediators Gene Polymorphisms in Preeclampsia

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dc.contributor.authorFranchim, Camila Sommerauer [UNIFESP]
dc.contributor.authorSass, Nelson [UNIFESP]
dc.contributor.authorMattar, Rosiane [UNIFESP]
dc.contributor.authorPendeloski, Karen P. T. [UNIFESP]
dc.contributor.authorLin, Lawrence Hsu [UNIFESP]
dc.contributor.authorTorloni, Maria R. [UNIFESP]
dc.contributor.authorDaher, Silvia [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:06:03Z
dc.date.available2016-01-24T14:06:03Z
dc.date.issued2011-01-01
dc.description.abstractObjective. To assess a possible relation between proinflammatory mediators (IL-1R1, IL-12, IL-18, TLR-2, and TLR-4) gene polymorphisms and preeclampsia (PE). Methods. Genotyping was performed on 109 preeclamptic patients and 174 healthy fertile women with at least two previous successful pregnancies (controls). chi(2) or Fisher's exact test were used to compare genotype frequencies. the control group included 174 pregnant women matched by race to the study group. Results. Genotypic and allelic distributions for all six polymorphisms were similar between the study and control groups. IL-1R1 (PstI, rs2234650): p = 0.82; IL-12 (+1188, rs3212227): p = 0.93; IL-18 (-137, rs187238): p = 0.74; IL-18 (-607, rs1946519): p = 0.22; TLR-2 (+2258, rs5743708): p = 0.97; and TLR-4 (+896, rs4986790): p = 0.23. Conclusion. the analyzed gene polymorphisms are not associated with PE.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Obstet, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Obstet, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipIDFAPESP: 07/56791-5
dc.description.sponsorshipIDFAPESP: 07/57446-0
dc.format.extent338-346
dc.identifierhttp://dx.doi.org/10.3109/10641950903455389
dc.identifier.citationHypertension in Pregnancy. London: Informa Healthcare, v. 30, n. 3, p. 338-346, 2011.
dc.identifier.doi10.3109/10641950903455389
dc.identifier.issn1064-1955
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33347
dc.identifier.wosWOS:000292566200010
dc.language.isoeng
dc.publisherInforma Healthcare
dc.relation.ispartofHypertension in Pregnancy
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.subjectCytokinesen
dc.subjectInflammatory mediatorsen
dc.subjectPreeclampsiaen
dc.subjectGenetic Polymorphismen
dc.titleInflammatory Mediators Gene Polymorphisms in Preeclampsiaen
dc.typeinfo:eu-repo/semantics/article
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