Risk factors for age at onset of dementia due to Alzheimer's disease in a sample of patients with low mean schooling from São Paulo, Brazil

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dc.contributor.authorOliveira, Fabricio Ferreira de [UNIFESP]
dc.contributor.authorBertolucci, Paulo Henrique Ferreira [UNIFESP]
dc.contributor.authorChen, Elizabeth Suchi [UNIFESP]
dc.contributor.authorSmith, Marilia Cardoso [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:37:55Z
dc.date.available2016-01-24T14:37:55Z
dc.date.issued2014-10-01
dc.description.abstractObjective: in view of the mild effects of pharmacological treatment for dementia due to Alzheimer's disease (AD), the search for modifiable risk factors is an important challenge. Although risk factors for AD are widely recognized, elements that influence the time of onset of the dementia syndrome have not been comprehensively reported. We aimed to investigate which risk factors might be associated with the age at onset of AD in a sample of patients with low mean schooling from São Paulo, Brazil.Methods: We included 210 consecutive patients with late-onset AD to investigate whether education, gender, nationality, urban living and sanitation, occupation, cognitive and physical inactivity, head trauma, depression, systemic infections, surgical interventions, cerebrovascular risk factors, family history of neurodegenerative diseases or cardiovascular diseases and apolipoprotein E gene (APOE) haplotypes might be related to the age at AD onset.Results: Each copy of APOE-epsilon 4 led to onset of AD almost 2 years earlier, while depression, smoking, higher body mass index and family history of cardiovascular diseases were also highly significant. Protective factors included non-Brazilian nationality, use of a pacemaker and waist circumference. Cerebrovascular risk factors had a mild combined effect for earlier onset of AD.Conclusion: APOE haplotypes, depression, nationality and cerebrovascular risk factors were the most important elements to influence the age at AD onset in this sample, whereas gender, education, occupation and physical activities had no isolated effects over the age at onset of this dementia syndrome. Copyright (C) 2014 John Wiley & Sons, Ltd.en
dc.description.affiliationFed Univ São Paulo UNIFESP, Escola Paulista Med, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliationFed Univ São Paulo UNIFESP, Escola Paulista Med, Dept Morphol & Genet, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Escola Paulista Med, Dept Neurol & Neurosurg, São Paulo, Brazil
dc.description.affiliationUnifespFed Univ São Paulo UNIFESP, Escola Paulista Med, Dept Morphol & Genet, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.format.extent1033-1039
dc.identifierhttp://dx.doi.org/10.1002/gps.4094
dc.identifier.citationInternational Journal of Geriatric Psychiatry. Hoboken: Wiley-Blackwell, v. 29, n. 10, p. 1033-1039, 2014.
dc.identifier.doi10.1002/gps.4094
dc.identifier.issn0885-6230
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/38261
dc.identifier.wosWOS:000343012200006
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofInternational Journal of Geriatric Psychiatry
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.subjectAlzheimer's diseaseen
dc.subjectdementiaen
dc.subjectrisk factorsen
dc.subjectcerebrovascular disordersen
dc.subjecteducational statusen
dc.subjectneurodegenerative diseasesen
dc.titleRisk factors for age at onset of dementia due to Alzheimer's disease in a sample of patients with low mean schooling from São Paulo, Brazilen
dc.typeinfo:eu-repo/semantics/article
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