Atypical antipsychotic clozapine reversed deficit on prepulse inhibition of the acoustic startle reflex produced by microinjection of DOI into the inferior colliculus in rats

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dc.citation.volume325
dc.contributor.authorOliveira, Rodolpho Pereira de [UNIFESP]
dc.contributor.authorNagaishi, Karen Yuriko [UNIFESP]
dc.contributor.authorSilva, Regina Cláudia Barbosa da [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.coverageAmsterdam
dc.date.accessioned2020-07-13T11:53:13Z
dc.date.available2020-07-13T11:53:13Z
dc.date.issued2017
dc.description.abstractDysfunctions of the serotonergic system have been suggested to be important in the neurobiology of schizophrenia. Patients with schizophrenia exhibit deficits in an operational measure of sensorimotor gating: prepulse inhibition (PPI) of startle. PPI is the normal reduction in the startle response caused by a low intensity non-startling stimulus (prepulse) which is presented shortly before the startle stimulus (pulse). Tile hallucinogen 2,5-dimethoxy-4-iodoamphetamine (DOI), a 5-hydroxytryptamine(HT)2 receptor agonist disrupted PPI in rats. The inferior colliculus (IC) is a critical nucleus of the auditory pathway mediating acoustic PPI. The activation of the IC by the acoustic prepulse reduces startle magnitude. The present study investigated the role of serotonergic transmission in the IC on the expression of acoustic PPI. For that we investigated whether 5-HT2A receptor activation or blockade would affect this response. Unilateral microinjection of DOI (10 mu g,/0.3 mu L ) into the IC disrupted PPI, while microinjection of the 5-HT2A receptor antagonist ritanserin (4 p,mu g/0.3 mu l), into this structure did not alter PPI. We also examined the ability of the atypical antipsychotic clozapine (5.0 mg/kg I.P.) to reverse the disruption of PPI produced by unilateral microinjections of DOI into the IC of rats. Pretreatment with clozapine blocked DOI-induced disruption of PPI. Altogether, these results suggest that serotonin-mediated mechanisms of the IC are involved in the expression of PPI in rodents and that this response is sensitive to atypical antipsychotic clozapine.en
dc.description.affiliationUniv Fed Sao Paulo, Unifesp, Dept Biociencias, Lab Psicobiol Esquizofrenia, R Silva Jardim 136, BR-11015020 Santos, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Unifesp, Dept Biociencias, Lab Psicobiol Esquizofrenia, R Silva Jardim 136, BR-11015020 Santos, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt
dc.description.sponsorshipIDFAPESP: 2014/16634-1
dc.format.extent72-78
dc.identifierhttps://dx.doi.org/10.1016/j.bbr.2017.01.053
dc.identifier.citationBehavioural Brain Research. Amsterdam, v. 325, p. 72-78, 2017.
dc.identifier.doi10.1016/j.bbr.2017.01.053
dc.identifier.issn0166-4328
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/54459
dc.identifier.wosWOS:000401594900009
dc.language.isoeng
dc.publisherElsevier Science Bv
dc.relation.ispartofBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectSchizophreniaen
dc.subjectInferior colliculusen
dc.subjectDOIen
dc.subject5-HT2 receptorsen
dc.subjectClozapineen
dc.subjectPrepulse inhibitionen
dc.titleAtypical antipsychotic clozapine reversed deficit on prepulse inhibition of the acoustic startle reflex produced by microinjection of DOI into the inferior colliculus in ratsen
dc.typeinfo:eu-repo/semantics/article
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