Low molecular weight heparins: Structural differentiation by spectroscopic and multivariate approaches

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dc.contributor.authorLima, Marcelo Andrade de [UNIFESP]
dc.contributor.authorFarias, Eduardo Henrique Cunha de [UNIFESP]
dc.contributor.authorRudd, Timothy R.
dc.contributor.authorEbner, Lyvia Ferreira [UNIFESP]
dc.contributor.authorGesteira, Tarsis Ferreira [UNIFESP]
dc.contributor.authorMendes, Aline [UNIFESP]
dc.contributor.authorBoucas, Rodrigo Ippolito [UNIFESP]
dc.contributor.authorMartins, João Roberto Maciel [UNIFESP]
dc.contributor.authorHoppensteadt, Debra
dc.contributor.authorFareed, Jawed
dc.contributor.authorYates, Edwin A.
dc.contributor.authorSassaki, Guilherme L.
dc.contributor.authorTersariol, Ivarne Luis dos Santos [UNIFESP]
dc.contributor.authorNader, Helena Bonciani [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniv Liverpool
dc.contributor.institutionLoyola Univ
dc.contributor.institutionUniv Fed Parana
dc.date.accessioned2016-01-24T14:16:54Z
dc.date.available2016-01-24T14:16:54Z
dc.date.issued2011-07-01
dc.description.abstractVarious branded low molecular weight heparins (LMWHs) have been used for the treatment and prevention of thrombotic for over 20 years. With the introduction of generic LMWHs and the recent events involving heparin contamination, a great deal of effort is being expended in investigating ways of monitoring and regulating this class of complex drugs. in this paper, we present the characterization of different forms of LMWHs, as well as the comparison of 5 enoxaparin copies from different manufactures. the data suggests that, while some of these drugs are structurally comparable, specific analytical methods as well as biological and pharmacological tests may be used to address their similarity, quality and potential interchangeability. the proposed approach may also be useful in comparing biosimilar and branded LMWHs. (C) 2011 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Bioquim, BR-04044020 São Paulo, SP, Brazil
dc.description.affiliationUniv Liverpool, Sch Biol Sci, Liverpool L69 7ZB, Merseyside, England
dc.description.affiliationLoyola Univ, Med Ctr, Dept Pathol, Maywood, IL 60153 USA
dc.description.affiliationUniv Fed Parana, Lab Quim Carboidratos, Dept Bioquim & Biol Mol, BR-81531980 Curitiba, Parana, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Bioquim, BR-04044020 São Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent903-909
dc.identifierhttp://dx.doi.org/10.1016/j.carbpol.2011.04.021
dc.identifier.citationCarbohydrate Polymers. Oxford: Elsevier B.V., v. 85, n. 4, p. 903-909, 2011.
dc.identifier.doi10.1016/j.carbpol.2011.04.021
dc.identifier.fileWOS000291838900026.pdf
dc.identifier.issn0144-8617
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33811
dc.identifier.wosWOS:000291838900026
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofCarbohydrate Polymers
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectBiosimilaren
dc.subjectLow molecular weight heparinen
dc.subjectNuclear magnetic resonanceen
dc.subjectCircular dichroismen
dc.subjectScanning UVen
dc.subjectPrincipal component analysisen
dc.titleLow molecular weight heparins: Structural differentiation by spectroscopic and multivariate approachesen
dc.typeinfo:eu-repo/semantics/article
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