Idiopathic focal segmental glomerulosclerosis and HLA antigens

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dc.contributor.authorGerbase-Lima, Maria [UNIFESP]
dc.contributor.authorPereira-Santos, A. [UNIFESP]
dc.contributor.authorSesso, Ricardo de Castro Cintra [UNIFESP]
dc.contributor.authorTemin, Julia
dc.contributor.authorAragão, E.s.
dc.contributor.authorAjzen, Horacio [UNIFESP]
dc.contributor.institutionA01
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:24:42Z
dc.date.available2015-06-14T13:24:42Z
dc.date.issued1998-03-01
dc.description.abstractThe objective of the present study was to investigate a possible association between HLA class II antigens and idiopathic focal segmental glomerulosclerosis (FSGS). HLA-A, -B, -DR and -DQ antigens were determined in 19 Brazilian patients (16 white subjects and three subjects of Japanese origin) with biopsy-proven FSGS. Comparison of the HLA antigen frequencies between white patients and white local controls showed a significant increase in HLA-DR4 frequency among FSGS patients (37.7 vs 17.2%, P<0.05). In addition, the three patients of Japanese extraction, not included in the statistical analysis, also presented HLA-DR4. In conclusion, our data confirm the association of FSGS with HLA-DR4 previously reported by others, thus providing further evidence for a role of genes of the HLA complex in the susceptibility to this diseaseen
dc.description.affiliationA01
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP)
dc.description.affiliationUnifespUNIFESP
dc.description.sourceSciELO
dc.format.extent387-389
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X1998000300010
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 31, n. 3, p. 387-389, 1998.
dc.identifier.doi10.1590/S0100-879X1998000300010
dc.identifier.fileS0100-879X1998000300010.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X1998000300010
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/590
dc.identifier.wosWOS:000073337200010
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectfocal segmental glomerulosclerosisen
dc.subjectgeneticsen
dc.subjectHLA antigensen
dc.subjectMHCen
dc.titleIdiopathic focal segmental glomerulosclerosis and HLA antigensen
dc.typeinfo:eu-repo/semantics/article
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