Gamma ventral capsulotomy for treatment of resistant obsessive-compulsive disorder: A structural MRI pilot prospective study

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dc.contributor.authorCecconia, Janaina Philippi
dc.contributor.authorLopes, Antonio Carlos
dc.contributor.authorDuran, Fabio Luis de Souza
dc.contributor.authorSantos, Luciana Cristina
dc.contributor.authorHoexter, Marcelo Queiroz [UNIFESP]
dc.contributor.authorGentil, Andre Felix
dc.contributor.authorCanteras, Miguel Montes
dc.contributor.authorCastro, Claudio Campi de
dc.contributor.authorNoren, George
dc.contributor.authorGreenberg, Benjamin D.
dc.contributor.authorRauch, Scott L.
dc.contributor.authorBusatto, Geraldo F.
dc.contributor.authorMiguel, Euripedes Constantino
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionHosp Santa Paula
dc.contributor.institutionBrown Univ
dc.contributor.institutionHarvard Univ
dc.contributor.institutionMassachusetts Gen Hosp
dc.date.accessioned2016-01-24T13:51:58Z
dc.date.available2016-01-24T13:51:58Z
dc.date.issued2008-12-12
dc.description.abstractObjective: the purpose of this study was to investigate regional structural abnormalities in the brains of five patients with refractory obsessive-compulsive disorder (OCD) submitted to gamma ventral capsulotomy. Methods: We acquired morphometric magnetic resonance imaging (MRI) data before and after 1 year of radiosurgery using a 1.5-T MRI scanner. Images were spatially normalized and segmented using optimized voxel-based morphometry (VBM) methods. Voxelwise statistical comparisons between pre- and post-surgery MRI scans were performed using a general linear model. Findings in regions predicted a priori to show volumetric changes (orbitofrontal cortex, anterior cingulate gyrus, basal ganglia and thalamus) were reported as significant if surpassing a statistical threshold of p<0.001 (uncorrected for multiple comparisons). Results: We detected a significant regional postoperative increase in gray matter volume in the right inferior frontal gyri (Brodmann area 47, BA47) when comparing all patients pre and postoperatively. Conclusions: Our results support the current theory of frontal-striatal-thalamic-cortical (FSTC) circuitry involvement in OCD pathogenesis. Gamma ventral capsulotomy is associated with neurobiological changes in the inferior orbitofrontal cortex in refractory OCD patients. (C) 2008 Elsevier Ireland Ltd. All rights reserved.en
dc.description.affiliationUniv São Paulo, Sch Med, Dept Psychiat,FMUSP, Obsess Compuls Spectrum Disorders Program PROTOC, BR-01060970 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.affiliationHosp Santa Paula, Inst Neurol Radiosurg, São Paulo, Brazil
dc.description.affiliationBrown Univ, Dept Psychiat & Human Behav, Providence, RI 02912 USA
dc.description.affiliationBrown Univ, Dept Clin Neurosci Neurosurg, Providence, RI 02912 USA
dc.description.affiliationHarvard Univ, Sch Med, Boston, MA USA
dc.description.affiliationMassachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychiat, São Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico a Tecnologico
dc.description.sponsorshipIDFAPESP: 1999/08560-6
dc.description.sponsorshipIDFAPESP: 2005/55628-08
dc.description.sponsorshipIDConselho Nacional de Desenvolvimento Cientifico a Tecnologico: 305548/2005-0
dc.format.extent138-142
dc.identifierhttp://dx.doi.org/10.1016/j.neulet.2008.09.061
dc.identifier.citationNeuroscience Letters. Clare: Elsevier B.V., v. 447, n. 2-3, p. 138-142, 2008.
dc.identifier.doi10.1016/j.neulet.2008.09.061
dc.identifier.issn0304-3940
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31097
dc.identifier.wosWOS:000261549300009
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofNeuroscience Letters
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectObsessive-compulsive disorder (OCD)en
dc.subjectMagnetic resonance imaging (MRI)en
dc.subjectVoxel-based morphometryen
dc.subjectRadiosurgeryen
dc.subjectNeurosurgeryen
dc.titleGamma ventral capsulotomy for treatment of resistant obsessive-compulsive disorder: A structural MRI pilot prospective studyen
dc.typeinfo:eu-repo/semantics/article
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