Impact of hippocampal subfield histopathology in episodic memory impairment in mesial temporal lobe epilepsy and hippocampal sclerosis

Página do item simplificado
dc.citation.volume75
dc.contributor.authorComper, Sandra Mara [UNIFESP]
dc.contributor.authorJardim, Anaclara Prada [UNIFESP]
dc.contributor.authorCorso, Jeana Torres [UNIFESP]
dc.contributor.authorGaca, Larissa Botelho [UNIFESP]
dc.contributor.authorSilva Noffs, Maria Helena [UNIFESP]
dc.contributor.authorPenteado Lancellotti, Carmen Lucia
dc.contributor.authorCavalheiro, Esper Abrao [UNIFESP]
dc.contributor.authorCenteno, Ricardo Silva [UNIFESP]
dc.contributor.authorTargas Yacubian, Elza Marcia [UNIFESP]
dc.coverageSan Diego
dc.date.accessioned2020-08-04T13:40:04Z
dc.date.available2020-08-04T13:40:04Z
dc.date.issued2017
dc.description.abstractObjective: The objective of the study was to analyze preoperative visual and verbal episodic memories in a homogeneous series of patients with mesial temporal lobe epilepsy (MTLE) and unilateral hippocampal sclerosis (HS) submitted to corticoamygdalohippocampectomy and its association with neuronal cell density of each hippocampal subfield. Methods: The hippocampi of 72 right-handed patients were collected and prepared for histopathological examination. Hippocampal sclerosis patterns were determined, and neuronal cell density was calculated. Preoperatively, two verbal and two visual memory tests (immediate and delayed recalls) were applied, and patients were divided into two groups, left and right MTLE (36/36). Results: There were no statistical differences between groups regarding demographic and clinical data. Cornu Ammonis 4 (CA4) neuronal density was significantly lower in the right hippocampus compared with the left (p = 0.048). The groups with HS presented different memory performance the right HS were worse in visual memory test [Complex Rey Figure, immediate (p = 0.001) and delayed (p = 0.009)], but better in one verbal task [RAVLT delayed (p = 0.005)]. Multiple regression analysis suggested that the verbal memory performance of the group with left HS was explained by CA1 neuronal density since both tasks were significantly influenced by CA1 [Logical Memory immediate recall (p = 0.050) and Logical Memory and RAVLT delayed recalls (p = 0.004 and p = 0.001, respectively)]. For patients with right HS, both CA1 subfield integrity (p = 0.006) and epilepsy duration (p = 0.012) explained Complex Rey Figure immediate recall performance. Ultimately, epilepsy duration also explained the performance in the Complex Rey Figure delayed recall (p < 0.001). Significance: Cornu Ammonis 1 (CA1) hippocampal subfield was related to immediate and delayed recalls of verbal memory tests in left HS, while CAl and epilepsy duration were associated with visual memory performance in patients with right HS. (C) 2017 Elsevier Inc. All rights reserved.en
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Neurol & Neurosurg, Clin Neurol Sect, Sao Paulo, SP, Brazil
dc.description.affiliationFac Ciencias Med Santa Casa Sao Paulo, Dept Pathol Sci, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Neurol & Neurosurg, Neurosci Sect, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Neurol & Neurosurg, Neurosurg Sect, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Neurol & Neurosurg, Clin Neurol Sect, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Neurol & Neurosurg, Neurosci Sect, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Neurol & Neurosurg, Neurosurg Sect, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPQ)
dc.format.extent183-189
dc.identifierhttp://dx.doi.org/10.1016/j.yebeh.2017.08.013
dc.identifier.citationEpilepsy & Behavior. San Diego, v. 75, p. 183-189, 2017.
dc.identifier.doi10.1016/j.yebeh.2017.08.013
dc.identifier.issn1525-5050
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57268
dc.identifier.wosWOS:000412267000030
dc.language.isoeng
dc.publisherAcademic Press Inc Elsevier Science
dc.relation.ispartofEpilepsy & Behavior
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectHippocampal sclerosisen
dc.subjectHippocampal subfieldsen
dc.subjectNeuronal cell densityen
dc.subjectTemporal lobe epilepsyen
dc.subjectVerbal memoryen
dc.subjectVisual memoryen
dc.titleImpact of hippocampal subfield histopathology in episodic memory impairment in mesial temporal lobe epilepsy and hippocampal sclerosisen
dc.typeinfo:eu-repo/semantics/article
Arquivos
Coleções
EPM - Artigos