An alternative non-invasive treatment for Peyronie's disease

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dc.contributor.authorClaro, Joaquim A. [UNIFESP]
dc.contributor.authorPasserotti, Carlo Camargo [UNIFESP]
dc.contributor.authorFigueiredo Neto, Antonio C. [UNIFESP]
dc.contributor.authorNardozza Júnior, Archimedes [UNIFESP]
dc.contributor.authorOrtiz, Valdemar [UNIFESP]
dc.contributor.authorSrougi, Miguel [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:30:23Z
dc.date.available2015-06-14T13:30:23Z
dc.date.issued2004-06-01
dc.description.abstractOBJECTIVE: Surgical correction of the deformity and plaque caused by Peyronie's disease has some important disadvantages and extracorporeal shockwave therapy (ESWT) emerged as a new promising therapy. We evaluated prospectively the efficacy and safety of the association of high dose vitamin E and ESWT as a non-invasive treatment for the disease. MATERIALS AND METHODS: Twenty-five patients 42 to 68 years old (mean = 54) presenting penile deviation and sexual distress caused by Peyronie's disease were treated in a non-invasive manner. The time of penile deviation ranged from 16 to 52 months (mean = 30). All patients had previous unsuccessful treatment for Peyronie's disease. The angulation's deformity of the penis was assessed by photography at home. The patients received vitamin E (l.200 mg daily) during 3 months and underwent 3 to 6 sessions (mean = 3) of ESWT (3,000 to 4,000 shockwaves) at a power level of l to 2 at 1-week intervals. RESULTS: From 25 patients treated, 16 (64%) reported an improvement in penile angulation, with a mean reduction of 21 degrees (10 to 40). Eight patients reported improvement in their spontaneous erections. Overall, the patients presented only minimal bruising at the site of treatment and skin hematoma. Four patients presented urethral bleeding. The mean angulation after treatment in the control group was 48.67 degrees (30 - 70) and in the study group was 24.42 degrees (0 - 70), statistically significant. CONCLUSION: Considering the common complications and the unsatisfactory outcome of the surgical correction for Peyronie's disease, the association of high dose vitamin E and ESWT represents a good option for a non-invasive, effective and safe treatment of the penile deformity.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Division of Urology
dc.description.affiliationUnifespUNIFESP, EPM, Division of Urology
dc.description.sourceSciELO
dc.format.extent199-204
dc.identifierhttp://dx.doi.org/10.1590/S1677-55382004000300004
dc.identifier.citationInternational braz j urol. Sociedade Brasileira de Urologia, v. 30, n. 3, p. 199-204, 2004.
dc.identifier.doi10.1590/S1677-55382004000300004
dc.identifier.fileS1677-55382004000300004.pdf
dc.identifier.issn1677-5538
dc.identifier.scieloS1677-55382004000300004
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/2100
dc.language.isoeng
dc.publisherSociedade Brasileira de Urologia
dc.relation.ispartofInternational braz j urol
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectpenisen
dc.subjectPeyronie's diseaseen
dc.subjectextracorporeal shockwave lithotripsyen
dc.subjectvitamin Een
dc.subjecttreatmenten
dc.titleAn alternative non-invasive treatment for Peyronie's diseaseen
dc.typeinfo:eu-repo/semantics/article
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