Osteoporosis and autophagy: What is the relationship?

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dc.citation.issue2
dc.citation.volume63
dc.contributor.authorFlorencio-Silva, Rinaldo [UNIFESP]
dc.contributor.authorda Silva Sasso, Gisela Rodrigues [UNIFESP]
dc.contributor.authorSimoes, Manuel de Jesus [UNIFESP]
dc.contributor.authorSimoes, Ricardo Santos
dc.contributor.authorPinheiro Baracat, Maria Candida
dc.contributor.authorSasso-Cerri, Estela
dc.contributor.authorCerri, Paulo Sergio
dc.coverageSao Paulo
dc.date.accessioned2020-07-17T14:03:02Z
dc.date.available2020-07-17T14:03:02Z
dc.date.issued2017
dc.description.abstractAutophagy is a survival pathway wherein non-functional proteins and organelles are degraded in lysosomes for recycling and energy production. Therefore, autophagy is fundamental for the maintenance of cell viability, acting as a quality control process that prevents the accumulation of unnecessary structures and oxidative stress. Increasing evidence has shown that autophagy dysfunction is related to several pathologies including neurodegenerative diseases and cancer. Moreover, recent studies have shown that autophagy plays an important role for the maintenance of bone homeostasis. For instance, in vitro and animal and human studies indicate that autophagy dysfunction in bone cells is associated with the onset of bone diseases such as osteoporosis. This review had the purpose of discussing the issue to confirm whether a relationship between autophagy dysfunction and osteoporosis exits.en
dc.description.affiliationUniv Fed Sao Paulo Unifesp, Dept Morphol & Genet, Div Histol & Struct Biol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Fed Sao Paulo, Dept Gynecol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Sao Paulo FMUSP, Fac Med, Dept Obstet & Gynecol, Sao Paulo, SP, Brazil
dc.description.affiliationFMUSP, Dept Obstet & Gynecol, Sao Paulo, SP, Brazil
dc.description.affiliationUniv Estadual Paulista Unesp, Fac Dent Araraquara, Dept Morphol, Lab Histol & Embryol, Araraquara, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo Unifesp, Dept Morphol & Genet, Div Histol & Struct Biol, Sao Paulo, SP, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, Dept Gynecol, Sao Paulo, SP, Brazil
dc.description.sourceWeb of Science
dc.format.extent173-179
dc.identifierhttp://dx.doi.org/10.1590/1806-9282.63.02.173
dc.identifier.citationRevista Da Associacao Medica Brasileira. Sao Paulo, v. 63, n. 2, p. 173-179, 2017.
dc.identifier.doi10.1590/1806-9282.63.02.173
dc.identifier.fileWOS000397875400013.pdf
dc.identifier.issn0104-4230
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/55138
dc.identifier.wosWOS:000397875400013
dc.language.isoeng
dc.publisherAssoc Medica Brasileira
dc.relation.ispartofRevista Da Associacao Medica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectautophagyen
dc.subjectbone tissueen
dc.subjectosteoblasten
dc.subjectosteocyteen
dc.subjectosteoclasten
dc.subjectosteoporosisen
dc.titleOsteoporosis and autophagy: What is the relationship?en
dc.typeinfo:eu-repo/semantics/article
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