Allergy to Cockroaches: Challenges in Diagnosis

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dc.contributor.authorLondres, Maria Isabela
dc.contributor.authorSarinho, Filipe W.
dc.contributor.authorMiranda, Paulo J.
dc.contributor.authorSolé, Dirceu [UNIFESP]
dc.contributor.authorSarinho, Emanuel [UNIFESP]
dc.contributor.institutionUniversidade Federal de Pernambuco (UFPE)
dc.contributor.institutionInst Med Integral Prof Fernando Figueim IMIP
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T16:52:48Z
dc.date.available2018-06-15T16:52:48Z
dc.date.issued2011-01-01
dc.description.abstractBackground: Blattella germanica and Periplaneta americana are the most common domestic species of cockroaches, found all over the world under favorable conditions. Allergen sensitivity can be detected through in vivo tests, such as skin prick tests (SPT) for immediate hypersensitivity and in vitro techniques, represented mainly by the sIgE determination. Nevertheless, there is no gold standard for the detection of hypersensitivity to cockroaches. This study aims to evaluate the agreement between skin prick test to different cockroach allergenic extracts with serum specific IgE determination in the diagnosis of cockroach allergy in asthmatic and non-asthmatic children.Methods: A case-control study involving 74 asthmatic and 42 non-asthmatic children aged between 6 and 14 years was conducted in Recife, Brazil. All individuals were submitted to a skin prick test (SPT) with Dermatophagoides pteronyssinus, D. farinae, Blomia tropicalis (IPI-ASAC (R)) and three different commercial cockroach extracts (Greer (R), Hollister-Stier (R), and IPI-ASAC Brasil (R)) of B. germanica and P. americana, and to the quantification of total serum IgE and specific serum IgE to B. germanica and P. americana.Results: The mean diameter of induced papule was considerably greater among the asthmatic patients when compared to non-asthmatic controls, regardless of the species or type of cockroach extract. The correlations between the various types of utilized extracts for the two species studied were not sufficiently strong. Hollister-Stier extract was the most sensible extract among asthmatics in this study for both B. germanica (54.1 % IN = 401) and P. americana (59.5 % IN = 441). A satisfactory correlation was found between the serum levels of specific IgE and total IgE for both species of cockroaches. The correlation of specific IgE serum level from each species with its respective SPT was not considered satisfactory.Conclusions: The weak correlation between the different extracts clearly indicates a need for standardization of the extracts for SPT for cockroach allergy diagnosis. According to this study, only a patient with high specific IgE serum levels and a positive SPT to a cockroach species should be truly classified as hypersensitive to B. germanica and/or P. americana. (Clin. Lab. 2011;57:969-974)en
dc.description.affiliationUniv Fed Pernambuco, Keizo Azatni LIKA Lab, Recife, PE, Brazil
dc.description.affiliationUniv Fed Pernambuco, Prof Pathol & Immunopathol, Recife, PE, Brazil
dc.description.affiliationInst Med Integral Prof Fernando Figueim IMIP, Recife, PE, Brazil
dc.description.affiliationUniv Fed Sao Paulo, UNIFESP, Sao Paulo, Brazil
dc.description.affiliationUniv Fed Pernambuco, Courses Child & Adolescent Hlth & Hlth Sci, Fed Univ Med Residency Coordinator Allergy & Immu, Recife, PE, Brazil
dc.description.affiliationUnifespUniv Fed Sao Paulo, UNIFESP, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.format.extent969-974
dc.identifierhttp://clinical-laboratory.de/issue/78
dc.identifier.citationClinical Laboratory. Heidelberg: Clin Lab Publ, v. 57, n. 11-12, p. 969-974, 2011.
dc.identifier.issn1433-6510
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/43367
dc.identifier.wosWOS:000298897400016
dc.language.isoeng
dc.publisherClin Lab Publ
dc.relation.ispartofClinical Laboratory
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.subjectAllergyen
dc.subjectcockroachen
dc.subjectskin testen
dc.subjectdiagnosisen
dc.titleAllergy to Cockroaches: Challenges in Diagnosisen
dc.typeinfo:eu-repo/semantics/article
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