Changes in sodium appetite evoked by lesions of the commissural nucleus of the tractus solitarius

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dc.contributor.authorOgihara, Cristiana Akemi [UNIFESP]
dc.contributor.authorSchoorlemmer, Gerhardus Hermanus Maria [UNIFESP]
dc.contributor.authorColombari, Eduardo [UNIFESP]
dc.contributor.authorSato, Monica Akemi [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionFaculdade de Medicina do ABC Departamento de Fisiologia
dc.date.accessioned2015-06-14T13:39:15Z
dc.date.available2015-06-14T13:39:15Z
dc.date.issued2009-06-01
dc.description.abstractAblation of the area postrema/caudal nucleus of the tractus solitarius (NTS) complex increases sodium intake, but the effect of selective lesions of the caudal NTS is not known. We measured depletion-induced sodium intake in rats with electrolytic lesions of the commissural NTS that spared the area postrema. One day after the lesion, rats were depleted of sodium with furosemide (10 mg/kg body weight, sc) and then had access to water and a sodium-deficient diet for 24 h when 1.8% NaCl was offered. Water and saline intakes were measured for 2 h. Saline intake was higher in lesioned than in sham-lesioned rats (mean ± SEM: 20 ± 2 vs 11 ± 3 mL/2 h, P < 0.05, N = 6-7). Saline intake remained elevated in lesioned rats when the tests were repeated 6 and 14 days after the lesion, and water intake in these two tests was increased as well. Water intake seemed to be secondary to saline intake both in lesioned and in sham-lesioned rats. A second group of rats was offered 10% sucrose for 2 h/day before and 2, 7, and 15 days after lesion. Sucrose intake in lesioned rats was higher than in sham-lesioned rats only 7 days after lesioning. A possible explanation for the increased saline intake in rats with commissural NTS lesions could be a reduced gastrointestinal feedback inhibition. The commissural NTS is probably part of a pathway for inhibitory control of sodium intake that also involves the area postrema and the parabrachial nucleus.en
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Departamento de Fisiologia
dc.description.affiliationFaculdade de Medicina do ABC Departamento de Fisiologia
dc.description.affiliationUnifespUNIFESP, EPM, Depto. de Fisiologia
dc.description.sourceSciELO
dc.format.extent561-566
dc.identifierhttp://dx.doi.org/10.1590/S0100-879X2009000600014
dc.identifier.citationBrazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 42, n. 6, p. 561-566, 2009.
dc.identifier.doi10.1590/S0100-879X2009000600014
dc.identifier.fileS0100-879X2009000600014.pdf
dc.identifier.issn0100-879X
dc.identifier.scieloS0100-879X2009000600014
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/5090
dc.identifier.wosWOS:000266135800002
dc.language.isoeng
dc.publisherAssociação Brasileira de Divulgação Científica
dc.relation.ispartofBrazilian Journal of Medical and Biological Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectNucleus of the solitary tracten
dc.subjectSodium appetiteen
dc.subjectSucroseen
dc.subjectFurosemideen
dc.titleChanges in sodium appetite evoked by lesions of the commissural nucleus of the tractus solitariusen
dc.typeinfo:eu-repo/semantics/article
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