Adhesion prevention in reabsorbable polyethylene glycol hydrogel (Coseal (R)) coated polypropylene mesh in rabbits

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dc.contributor.authorQuinino, Reynaldo Martins e [UNIFESP]
dc.contributor.authorAraujo-Filho, Irami
dc.contributor.authorLima, Francisco Piganataro
dc.contributor.authorBarbosa, Andre Luis Costa
dc.contributor.authorMaia, Tatiana de Carvalho
dc.contributor.authorGoldenberg, Alberto [UNIFESP]
dc.contributor.institutionRio Grande do Norte Fed Univ UFRN
dc.contributor.institutionUFRN
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2018-06-15T11:14:56Z
dc.date.available2018-06-15T11:14:56Z
dc.date.issued2013-12-01
dc.description.abstractPURPOSE: To evaluate of postoperative adhesion prevention and inflammatory response to polypropylene mesh, coated with reabsorbable hydrogel of polyethylene glycol (Coseal (R)) in contact with small bowel in an experimental model in rabbits.METHODS: Twenty female rabbits underwent laparotomy to implant two polypropylene meshes, 2x1cm, in the right and left flanks. The right mesh was protected with Coseal (R) spray (Group 1) and the left mesh received no treatment after implantation (Group 2). Thirty days after implantation, the rabbits underwent laparoscopy for adhesion analysis; the prosthesis were removed en bloc with the adjacent tissue for microscopic analysis of inflammation. Statistical analysis used the Mann-Whitney test.RESULTS: There was adhesion formation in five meshes (36%) from Group 1 and in 14 meshes (100%) from Group 2, with statistical significance (p<0.01). There were no differences in the inflammatory response, fibrosis, foreign body reaction, presence of collagen and type of inflammatory cells between the two groups.CONCLUSION: Polypropylene mesh coated with Coseal (R) showed a significantly lower rate of adhesion formation when compared with uncoated meshes, without interfering with inflammatory response.en
dc.description.affiliationRio Grande do Norte Fed Univ UFRN, Postgrad Program Interdisciplinary Surg Sci, BR-59072970 Natal, RN, Brazil
dc.description.affiliationRio Grande do Norte Fed Univ UFRN, Integrated Med Dept, BR-59072970 Natal, RN, Brazil
dc.description.affiliationUFRN, Dept Surg, Rio Grande Do Norte, Brazil
dc.description.affiliationUFRN, Dept Pathol, Rio Grande Do Norte, Brazil
dc.description.affiliationUFRN, Onofre Lopes Univ Hosp, Rio Grande Do Norte, Brazil
dc.description.affiliationSao Paulo Fed Univ UNIFESP, Dept Surg, Surg Gastroenterol Div, Sao Paulo, Brazil
dc.description.affiliationUnifespSao Paulo Fed Univ UNIFESP, Dept Surg, Surg Gastroenterol Div, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent807-814
dc.identifierhttp://dx.doi.org/10.1590/S0102-86502013001200001
dc.identifier.citationActa Cirurgica Brasileira. Sao Paulo: Acta Cirurgica Brasileira, v. 28, n. 12, p. 807-814, 2013.
dc.identifier.doi10.1590/S0102-86502013001200001
dc.identifier.fileS0102-86502013001200001.pdf
dc.identifier.issn0102-8650
dc.identifier.scieloS0102-86502013001200001
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/41983
dc.identifier.wosWOS:000328649900001
dc.language.isoeng
dc.publisherActa Cirurgica Brasileira
dc.relation.ispartofActa Cirurgica Brasileira
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTissue Adhesionsen
dc.subjectPolyethylene Glycolsen
dc.subjectPolypropylenesen
dc.subjectRabbitsen
dc.titleAdhesion prevention in reabsorbable polyethylene glycol hydrogel (Coseal (R)) coated polypropylene mesh in rabbitsen
dc.typeinfo:eu-repo/semantics/article
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