Improved detection of incipient vascular changes by a biotechnological platform combining post mortem MRI in situ with neuropathology

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dc.contributor.authorGrinberg, Lea Tenenholz
dc.contributor.authorAmaro Junior, Edson
dc.contributor.authorSilva, Alexandre Valotta da [UNIFESP]
dc.contributor.authorSilva, Rafael Emidio da
dc.contributor.authorSato, Joao Ricardo
dc.contributor.authorSantos, Denis Dionizio dos
dc.contributor.authorPacheco, Silmara de Paula
dc.contributor.authorLucena Ferretti, Renata Eloah de
dc.contributor.authorParaizo Leite, Renata Elaine
dc.contributor.authorPasqualucci, Carlos Augusto
dc.contributor.authorTeipel, Stefan J.
dc.contributor.authorFlatz, Wilhelm H.
dc.contributor.authorHeinsen, Helmut
dc.contributor.authorBrazilian Aging Brain Study Grp
dc.contributor.institutionUniv Wurzburg
dc.contributor.institutionUniversidade de São Paulo (USP)
dc.contributor.institutionInst Israelita Ensino & Pesquisa Albert Einstein
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Federal do ABC (UFABC)
dc.contributor.institutionUniv Rostock
dc.contributor.institutionUniv Munich
dc.date.accessioned2016-01-24T13:58:37Z
dc.date.available2016-01-24T13:58:37Z
dc.date.issued2009-08-15
dc.description.abstractThe histopathological counterpart of white matter hyperintensities is a matter of debate. Methodological and ethical limitations have prevented this question to be elucidated.We want to introduce a protocol applying state-of-the-art methods in order to solve fundamental questions regarding the neuroimaging-neuropathological uncertainties comprising the most common white matter hyperintensities [WMHs] seen in aging. By this protocol, the correlation between signal features in in situ, post mortem MRI-derived methods, including DTI and MTR and quantitative and qualitative histopathology can be investigated. We are mainly interested in determining the precise neuroanatomical substrate of incipient WMHs. A major issue in this protocol is the exact co-registration of small lesion in a tridimensional coordinate system that compensates tissue deformations after histological processing.The protocol is based on four principles: post mortem MRI in situ performed in a short post mortem interval, minimal brain deformation during processing, thick serial histological sections and computer-assisted 3D reconstruction of the histological sections.This protocol will greatly facilitate a systematic study of the location, pathogenesis, clinical impact, prognosis and prevention of WMHs. (C) 2009 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniv Wurzburg, Morphol Brain Res Unit, Psychiat Clin, D-97080 Wurzburg, Germany
dc.description.affiliationUniv São Paulo, Sch Med, Dept Pathol, Aging Brain Project, BR-01246903 São Paulo, Brazil
dc.description.affiliationInst Israelita Ensino & Pesquisa Albert Einstein, BR-05651901 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept Radiol, BR-05403001 São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biosci, BR-11060001 Santos, Brazil
dc.description.affiliationFed Univ ABC, Ctr Math Computat & Cognit, Santo Andre, SP, Brazil
dc.description.affiliationUniv São Paulo, Autopsy Serv São Paulo City, BR-05403000 São Paulo, Brazil
dc.description.affiliationUniv São Paulo, Sch Med, Dept Pathol, BR-01246903 São Paulo, Brazil
dc.description.affiliationUniv Rostock, Dept Psychiat & Psychotherapy, D-18147 Rostock, Germany
dc.description.affiliationUniv Munich, D-81377 Munich, Germany
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biosci, BR-11060001 Santos, Brazil
dc.description.sourceWeb of Science
dc.format.extent2-8
dc.identifierhttp://dx.doi.org/10.1016/j.jns.2009.02.327
dc.identifier.citationJournal of the Neurological Sciences. Amsterdam: Elsevier B.V., v. 283, n. 1-2, p. 2-8, 2009.
dc.identifier.doi10.1016/j.jns.2009.02.327
dc.identifier.issn0022-510X
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/31744
dc.identifier.wosWOS:000268609400002
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofJournal of the Neurological Sciences
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectNeuroimagingen
dc.subjectMRIen
dc.subjectNeuropathologyen
dc.subjectAutopsyen
dc.subjectCorrelationen
dc.subjectMethodsen
dc.subject3D reconstructionen
dc.subjectWhite matter hyperintensitiesen
dc.subjectLeukoaraiosisen
dc.titleImproved detection of incipient vascular changes by a biotechnological platform combining post mortem MRI in situ with neuropathologyen
dc.typeinfo:eu-repo/semantics/article
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