Reciprocal interactions between MK-801, sleep deprivation and recovery in modulating rat behaviour

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dc.contributor.authorDubiela, Francisco Paulino [UNIFESP]
dc.contributor.authorMessias, Melissa Fudoli [UNIFESP]
dc.contributor.authorMoreira, Karin Di Monteiro [UNIFESP]
dc.contributor.authorZanlorenci, Lineane Helena Fernandes [UNIFESP]
dc.contributor.authorGrassl, Christian [UNIFESP]
dc.contributor.authorFrussa Filho, Roberto [UNIFESP]
dc.contributor.authorNobrega, Jose N.
dc.contributor.authorTufik, Sergio [UNIFESP]
dc.contributor.authorHipólide, Débora Cristina [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionCtr Addict & Mental Hlth
dc.date.accessioned2016-01-24T14:05:58Z
dc.date.available2016-01-24T14:05:58Z
dc.date.issued2011-01-01
dc.description.abstractIncreasing evidence indicates that sleep deprivation alters behavioural responses to various pharmacological agents which might be associated to changes in receptor systems. the present work addressed the effects of sleep deprivation and recovery on behavioural changes induced by MK-801, and investigated whether such effects are related to changes in NMDA receptor (NMDAR) binding. Male Wistar rats were deprived of sleep for 96 h using the platform method (SD group), or were sleep deprived and then allowed to recover sleep for 24 h (SR group). Animals were treated with saline or 0.05, 0.10 or 0.20 mg/kg MK-801 before testing in an open field arena and elevated plus maze. A separate set of animals was sacrificed for [(3)H]MK-801 binding analysis in 40 brain regions. MK-801-induced hyperlocomotion was facilitated in a dose-dependent fashion after SR, while SD-induced increase in grooming was antagonized by the drug. Anxiolytic effects of 0.05 and 0.10 mg/kg MK-801 were unaffected by SD or SR conditions. No significant differences among groups were found in NMDAR binding. These findings indicate that the combined effects of MK-801 and sleep deprivation and recovery interact in a complex fashion to affect rat behaviour. They further suggest that such effects cannot be attributed to altered NMDAR binding in brain. (C) 2010 Elsevier B.V. All rights reserved.en
dc.description.affiliationUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUniversidade Federal de São Paulo, Dept Pharmacol, São Paulo, Brazil
dc.description.affiliationCtr Addict & Mental Hlth, Neuroimaging Res Sect, Toronto, ON, Canada
dc.description.affiliationUniversidade Federal de São Paulo, Dept Biol Sci, Diadema, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Psychobiol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Pharmacol, São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Dept Biol Sci, Diadema, Brazil
dc.description.sourceWeb of Science
dc.description.sponsorshipAFIP
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.description.sponsorshipFADA
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 98/1403-3
dc.format.extent180-185
dc.identifierhttp://dx.doi.org/10.1016/j.bbr.2010.07.031
dc.identifier.citationBehavioural Brain Research. Amsterdam: Elsevier B.V., v. 216, n. 1, p. 180-185, 2011.
dc.identifier.doi10.1016/j.bbr.2010.07.031
dc.identifier.issn0166-4328
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/33275
dc.identifier.wosWOS:000285318500024
dc.language.isoeng
dc.publisherElsevier B.V.
dc.relation.ispartofBehavioural Brain Research
dc.rightsinfo:eu-repo/semantics/restrictedAccess
dc.rights.licensehttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.subjectRaten
dc.subjectSleep deprivationen
dc.subjectNMDA receptoren
dc.subjectMK-801en
dc.subjectLocomotor activityen
dc.titleReciprocal interactions between MK-801, sleep deprivation and recovery in modulating rat behaviouren
dc.typeinfo:eu-repo/semantics/article
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