Scaffolds of calcium phosphate cement containing chitosan and gelatin

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dc.contributor.authorRenó, C. O. [UNIFESP]
dc.contributor.authorLima, B.f.a.s. [UNIFESP]
dc.contributor.authorTrichês, Eliandra de Sousa [UNIFESP]
dc.contributor.authorBertran, C.a.
dc.contributor.authorMotisuke, Mariana [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.contributor.institutionUniversidade Estadual de Campinas (UNICAMP)
dc.date.accessioned2015-06-14T13:45:45Z
dc.date.available2015-06-14T13:45:45Z
dc.date.issued2013-12-01
dc.description.abstractCalcium phosphate cements (CPCs) have potential to be used on repairing damaged bones due to their moldability, bioactivity and bioresorbability. These materials combine calcium orthophosphate powders with a liquid leading to a paste that hardens spontaneously at low temperatures. Hence, CPCs could be applied as scaffolds to support cell/tissue growth. This paper studies CPC scaffolds processing by foaming cement's liquid phase in which was added gelatin and chitosan. The former acted to increase the foam stability while the ladder acted as a foaming agent. Moreover, these polymers would enhance scaffold's biological properties by controlling material's total porosity and in vivo resorption. The method proposed led to scaffolds with 58.71% porosity with sizes ranging from 160 to 760 µm and compressive strength of 0.70MPa. After foaming, pores' size, distribution and interconnectivity changed significantly leading to a material that could be applied on bone regeneration since it would allow nutrient's transport, cell attachment and an increase in material degradation rate.en
dc.description.affiliationFederal University of São Paulo Institute of Science and Technology Bioceramics Laboratory
dc.description.affiliationUniversity of Campinas Institute of Chemistry Physical Chemistry Department
dc.description.affiliationUnifespUNIFESP, Institute of Science and Technology Bioceramics Laboratory
dc.description.sourceSciELO
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.description.sponsorshipIDFAPESP: 2011/09240-9
dc.format.extent1362-1365
dc.identifierhttp://dx.doi.org/10.1590/S1516-14392013005000124
dc.identifier.citationMaterials Research. ABM, ABC, ABPol, v. 16, n. 6, p. 1362-1365, 2013.
dc.identifier.doi10.1590/S1516-14392013005000124
dc.identifier.fileS1516-14392013000600021.pdf
dc.identifier.issn1516-1439
dc.identifier.scieloS1516-14392013000600021
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/8096
dc.identifier.wosWOS:000328910600021
dc.language.isoeng
dc.publisherABM, ABC, ABPol
dc.relation.ispartofMaterials Research
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectscaffoldsen
dc.subjectcalcium phosphate cementsen
dc.subjectgelatinen
dc.subjectchitosanen
dc.titleScaffolds of calcium phosphate cement containing chitosan and gelatinen
dc.typeinfo:eu-repo/semantics/article
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