The use of transvaginal synthetic mesh for anterior vaginal wall prolapse repair: a randomized controlled trial

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dc.contributor.authorDelroy, Carlos Antonio [UNIFESP]
dc.contributor.authorCastro, Rodrigo de Aquino [UNIFESP]
dc.contributor.authorDias, Marcia M. [UNIFESP]
dc.contributor.authorFeldner Junior, Paulo Cezar [UNIFESP]
dc.contributor.authorBortolini, Maria Augusta Tezelli [UNIFESP]
dc.contributor.authorGirão, Manoel João Batista Castello [UNIFESP]
dc.contributor.authorSartori, Marair Gracio Ferreira [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2016-01-24T14:34:36Z
dc.date.available2016-01-24T14:34:36Z
dc.date.issued2013-11-01
dc.description.abstractThe aim of the study was to compare the efficacy and safety of transvaginal trocar-guided polypropylene mesh insertion with traditional colporrhaphy for treatment of anterior vaginal wall prolapse.This is a randomized controlled trial in which women with advanced anterior vaginal wall prolapse, at least stage II with Ba a parts per thousand yenaEuro parts per thousand+1 cm according to the Pelvic Organ Prolapse Quantification (POP-Q) classification, were randomly assigned to have either anterior colporrhaphy (n = 39) or repair using trocar-guided transvaginal mesh (n = 40). the primary outcome was objective cure rate of the anterior compartment (point Ba) assessed at the 12-month follow-up visit, with stages 0 and I defined as anatomical success. Secondary outcomes included quantification of other vaginal compartments (POP-Q points), comparison of quality of life by the prolapse quality of life (P-QOL) questionnaire, and complication rate between the groups after 1 year. Study power was fixed as 80 % with 5 % cutoff point (p < 0.05) for statistical significance.The groups were similar regarding demographic and clinical preoperative parameters. Anatomical success rates for colporrhaphy and repair with mesh placement groups were 56.4 vs 82.5 % (95 % confidence interval 0.068-0.54), respectively, and the difference between the groups was statistically significant (p = 0.018). Similar total complication rates were observed in both groups, with tape exposure observed in 5 % of the patients. There was a significant improvement in all P-QOL domains as a result of both procedures (p < 0.001), but they were not distinct between groups (p > 0.05).Trocar-guided transvaginal synthetic mesh for advanced anterior POP repair is associated with a higher anatomical success rate for the anterior compartment compared with traditional colporrhaphy. Quality of life equally improved after both techniques. However, the trial failed to detect differences in P-QOL scores and complication rates between the groups.en
dc.description.affiliationUniversidade Federal de São Paulo, Sect Urogynecol & Vaginal Surg, Dept Gynecol, BR-04534000 São Paulo, Brazil
dc.description.affiliationUnifespUniversidade Federal de São Paulo, Sect Urogynecol & Vaginal Surg, Dept Gynecol, BR-04534000 São Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent1899-1907
dc.identifierhttp://dx.doi.org/10.1007/s00192-013-2092-0
dc.identifier.citationInternational Urogynecology Journal. London: Springer London Ltd, v. 24, n. 11, p. 1899-1907, 2013.
dc.identifier.doi10.1007/s00192-013-2092-0
dc.identifier.fileWOS000325828800015.pdf
dc.identifier.issn0937-3462
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/36889
dc.identifier.wosWOS:000325828800015
dc.language.isoeng
dc.publisherSpringer
dc.relation.ispartofInternational Urogynecology Journal
dc.rightsinfo:eu-repo/semantics/openAccess
dc.rights.licensehttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.subjectColporrhaphyen
dc.subjectMeshen
dc.subjectPelvic organ prolapseen
dc.subjectPOP surgeryen
dc.subjectAnterior vaginal wallen
dc.subjectNazca TC (TM)en
dc.titleThe use of transvaginal synthetic mesh for anterior vaginal wall prolapse repair: a randomized controlled trialen
dc.typeinfo:eu-repo/semantics/article
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