Effect of sildenafil in cavernous arteries of patients with erectile dysfunction

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dc.contributor.authorClaro, Joaquim A [UNIFESP]
dc.contributor.authorXimenes, Sergio Felix [UNIFESP]
dc.contributor.authorNardozza Júnior, Archimedes [UNIFESP]
dc.contributor.authorAndrade, Enrico [UNIFESP]
dc.contributor.authorMessina, Leonardo [UNIFESP]
dc.contributor.authorSrougi, Miguel [UNIFESP]
dc.contributor.institutionUniversidade Federal de São Paulo (UNIFESP)
dc.date.accessioned2015-06-14T13:30:05Z
dc.date.available2015-06-14T13:30:05Z
dc.date.issued2003-08-01
dc.description.abstractINTRODUCTION: Sildenafil citrate is a type 5 phosphodiesterase inhibitor, which has demonstrated excellent results in the treatment of erectile dysfunction. The effect of sildenafil citrate in the cavernous arteries of patients with erectile dysfunction has not been established yet. The objective of this study was to assess the effect of sildenafil citrate in the cavernous arteries of patients with erectile dysfunction, following an intracavernous injection of alprostadil. MATERIALS AND METHODS: 29 male patients, with mean age of 53.8 years (32 to 75 years), were prospectively evaluated. The mean time with complaint of erectile dysfunction was 50.5 months (6 to 168 months). Each patient was his own control. Patients underwent a measurement of peak systolic velocity before and after use of sildenafil citrate associated with 5 micrograms of alprostadil, through ultrasonic velocitometry Knoll/MIDUS® system. In the interval between measurements, approximately 15 days, patients used 3 tablets of sildenafil at home with their partners. RESULTS: Using only 5 mcg of alprostadil, average peak systolic velocity was 23.9 cm/s, and when associated to 50 mg of sildenafil it was 24.8 cm/s. Despite the increase in the flow rate caused by sildenafil, the difference was not statistically significant, Zcalculated = - 0.695 NS (Wilcoxon test). Twenty one of the 29 patients (72.4%) showed global improvement in sexual performance with the use of sildenafil citrate at home. There was not a statistically significant correlation between the global response to sildenafil citrate and the increase in the peak systolic velocity. CONCLUSION: We concluded that, even though the use of 50 mg of sildenafil citrate associated with 5 mcg of alprostadil provides an increase in the peak systolic velocity of the cavernous arteries, there was no statistic difference in relation to alprostadil alone. There was no correlation between the global response to sildenafil and the increase in the peak systolic velocityen
dc.description.affiliationUniversidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Division of Urology
dc.description.affiliationUnifespUNIFESP, EPM, Division of Urology
dc.description.sourceSciELO
dc.format.extent320-327
dc.identifierhttp://dx.doi.org/10.1590/S1677-55382003000400006
dc.identifier.citationInternational braz j urol. Sociedade Brasileira de Urologia, v. 29, n. 4, p. 320-327, 2003.
dc.identifier.doi10.1590/S1677-55382003000400006
dc.identifier.fileS1677-55382003000400006.pdf
dc.identifier.issn1677-5538
dc.identifier.scieloS1677-55382003000400006
dc.identifier.urihttp://repositorio.unifesp.br/handle/11600/1791
dc.language.isoeng
dc.publisherSociedade Brasileira de Urologia
dc.relation.ispartofInternational braz j urol
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectpenisen
dc.subjectarteriesen
dc.subjectpenile erectionen
dc.subjectcorpus cavernosumen
dc.subjectphosphodiesterases inhibitorsen
dc.titleEffect of sildenafil in cavernous arteries of patients with erectile dysfunctionen
dc.typeinfo:eu-repo/semantics/article
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