Risk Factors Associated With Early Invasive Pulmonary Aspergillosis in Kidney Transplant Recipients: Results From a Multinational Matched Case-Control Study

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dc.citation.issue7
dc.citation.volume16
dc.contributor.authorLopez-Medrano, F.
dc.contributor.authorSilva, J. T.
dc.contributor.authorFernandez-Ruiz, M.
dc.contributor.authorCarver, P. L.
dc.contributor.authorvan Delden, C.
dc.contributor.authorMerino, E.
dc.contributor.authorPerez-Saez, M. J.
dc.contributor.authorMontero, M.
dc.contributor.authorCoussement, J.
dc.contributor.authorde Abreu Mazzolin, M. [UNIFESP]
dc.contributor.authorCervera, C.
dc.contributor.authorSantos, L.
dc.contributor.authorSabe, N.
dc.contributor.authorScemla, A.
dc.contributor.authorCordero, E.
dc.contributor.authorCruzado-Vega, L.
dc.contributor.authorMartin-Moreno, P. L.
dc.contributor.authorLen, O.
dc.contributor.authorRudas, E.
dc.contributor.authorPonce de Leon, A.
dc.contributor.authorArriola, M.
dc.contributor.authorLauzurica, R.
dc.contributor.authorDavid, M.
dc.contributor.authorGonzalez-Rico, C.
dc.contributor.authorHenriquez-Palop, F.
dc.contributor.authorFortun, J.
dc.contributor.authorNucci, M.
dc.contributor.authorManuel, O.
dc.contributor.authorPano-Pardo, J. R.
dc.contributor.authorMontejo, M.
dc.contributor.authorMunoz, P.
dc.contributor.authorSanchez-Sobrino, B.
dc.contributor.authorMazuecos, A.
dc.contributor.authorPascual, J.
dc.contributor.authorHorcajada, J. P.
dc.contributor.authorLecompte, T.
dc.contributor.authorLumbreras, C.
dc.contributor.authorMoreno, A.
dc.contributor.authorCarratala, J.
dc.contributor.authorBlanes, M.
dc.contributor.authorHernandez, D.
dc.contributor.authorHernandez-Mendez, E. A.
dc.contributor.authorFarinas, M. C.
dc.contributor.authorPerello-Carrascosa, M.
dc.contributor.authorMorales, J. M.
dc.contributor.authorAndres, A.
dc.contributor.authorAguado, J. M.
dc.coverageHoboken
dc.date.accessioned2020-08-14T13:44:26Z
dc.date.available2020-08-14T13:44:26Z
dc.date.issued2016
dc.description.abstractRisk factors for invasive pulmonary aspergillosis (IPA) after kidney transplantation have been poorly explored. We performed a multinational case-control study that included 51 kidney transplant (KT) recipients diagnosed with early (first 180 posttransplant days) IPA at 19 institutions between 2000 and 2013. Control recipients were matched (1:1 ratio) by center and date of transplantation. Overall mortality among cases was 60.8%, and 25.0% of living recipients experienced graft loss. Pretransplant diagnosis of chronic pulmonary obstructive disease (COPDen
dc.description.abstractodds ratio [OR]: 9.96en
dc.description.abstract95% confidence interval [CI]: 1.09-90.58en
dc.description.abstractp = 0.041) and delayed graft function (OR: 3.40en
dc.description.abstract95% CI: 1.08-10.73en
dc.description.abstractp = 0.037) were identified as independent risk factors for IPA among those variables already available in the immediate peritransplant period. The development of bloodstream infection (OR: 18.76en
dc.description.abstract95% CI: 1.04-339.37en
dc.description.abstractp = 0.047) and acute graft rejection (OR: 40.73, 95% CI: 3.63-456.98en
dc.description.abstractp = 0.003) within the 3 mo prior to the diagnosis of IPA acted as risk factors during the subsequent period. In conclusion, pretransplant COPD, impaired graft function and the occurrence of serious posttransplant infections may be useful to identify KT recipients at the highest risk of early IPA. Future studies should explore the potential benefit of antimold prophylaxis in this group. A multinational case-control study in kidney transplant recipients finds that pretransplant diagnosis of chronic obstructive pulmonary disease, delayed graft function, bloodstream infection and acute graft rejection identify patients at the highest risk for early invasive pulmonary aspergillosis.en
dc.description.affiliationUniv Complutense, Inst Invest Hosp Octubre I 12 12, Hosp Univ Octubre 12, Unit Infect Dis,Dept Med,Sch Med, Madrid, Spain
dc.description.affiliationUniv Michigan Hlth Syst, Ann Arbor, MI USA
dc.description.affiliationUniv Hosp Geneva, Dept Med Special, Infect Dis Serv, Geneva, Switzerland
dc.description.affiliationHosp Univ Gen, Infect Dis Unit, Alicante, Spain
dc.description.affiliationHosp del Mar, Hosp del Mar Med Res Inst IMIM, Dept Nephrol, Barcelona, Spain
dc.description.affiliationHosp del Mar, Hosp del Mar Med Res Inst IMIM, Dept Infect Dis, Barcelona, Spain
dc.description.affiliationUniv Libre Bruxelles, Hop Erasme, Dept Nephrol Dialysis & Kidney Transplantat, Brussels, Belgium
dc.description.affiliationUniv Fed Sao Paulo UNIFESP, Dept Med, Div Nephol, Sao Paulo, Brazil
dc.description.affiliationFundacao Oswaldo Ramos, Hosp Rim & Hipertensao, Sao Paulo, Brazil
dc.description.affiliationUniv Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Sch Med, Dept Infect Dis,Hosp Clin, Barcelona, Spain
dc.description.affiliationCoimbra Hosp & Univ Ctr, Dept Urol & Kidney Transplantat, Renal Transplantat Unit, Coimbra, Portugal
dc.description.affiliationHosp Univ Bellvitge, Inst Invest Biomed Bellvitge IDIBELL, Dept Infect Dis, Barcelona, Spain
dc.description.affiliationUniv Paris 05, Hop Necker Enfants Malad, AP HP,RTRS Centaure, Serv Nephrol & Transplantat Adulte,Sorbonne Paris, Paris, France
dc.description.affiliationHospit Univ Vigen del Rocio, Inst Biomed Sevilla IBIS, Infect Dis Unit, Seville, Spain
dc.description.affiliationHosp Univ La Fe, Dept Nephrol, Valencia, Spain
dc.description.affiliationUniv Navarra Clin, Dept Nephrol, Pamplona, Spain
dc.description.affiliationHosp Univ Vall dHebron, Vall dHebron Res Inst VHIR, Dept Infect Dis, Barcelona, Spain
dc.description.affiliationHosp Univ Carlos Haya, Dept Nephrol, Malaga, Spain
dc.description.affiliationInst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Transplantat, Mexico City, DF, Mexico
dc.description.affiliationClin Nefrol Urol & Enfermedades Cardiovasc, Santa Fe, NM, Argentina
dc.description.affiliationUniv Hosp Germans Trias & Pujol, Dept Nephrol, Barcelona, Spain
dc.description.affiliationUniv Hosp Birmingham NHS Fdn Trust, Dept Microbiol, Birmingham, W Midlands, England
dc.description.affiliationUniv Hosp Marques de Valdecilla, Dept Infect Dis, Santander, Spain
dc.description.affiliationUniv Hosp Doctor Negrin, Dept Nephrol, Las Palmas Gran Canaria, Spain
dc.description.affiliationUniv Hosp Ramon y Cajal, Dept Infect Dis, Madrid, Spain
dc.description.affiliationUniv Fed Rio de Janeiro, Univ Hosp Clementino Fraga Filho, Dept Internal Med Hematol Serv & Mycol Lab, Rio De Janeiro, Brazil
dc.description.affiliationUniv Hosp CHUV, Dept Infect Dis, Lausanne, Switzerland
dc.description.affiliationUniv Hosp CHUV, Transplantat Ctr, Lausanne, Switzerland
dc.description.affiliationUniv Lausanne, Lausanne, Switzerland
dc.description.affiliationUniv Autonoma Madrid, Hosp Univ La Paz, Dept Internal Med, Sch Med, Madrid, Spain
dc.description.affiliationHosp Univ Cruces, Dept Infect Dis, Bilbao, Spain
dc.description.affiliationHosp Gen Univ Gregorio Maranon, Dept Microbiol & Infect Dis, Madrid, Spain
dc.description.affiliationUniv Autonoma Madrid, Hosp Univ Puerta de Hierro Majadahonda, Sch Med, Dept Nephrol, Madrid, Spain
dc.description.affiliationHosp Univ Puerta del Mar, Dept Nephrol, Cadiz, Spain
dc.description.affiliationHosp Univ La Fe, Infect Dis Unit, Valencia, Spain
dc.description.affiliationHosp Univ Vall dHebron, Vall dHebron Res Inst VHIR, Dept Nephrol, Barcelona, Spain
dc.description.affiliationUniv Complutense, Hosp Univ Octubre 12, Inst Invest Hosp Octubre I 12 12, Dept Nephrol,Dept Med,Sch Med, Madrid, Spain
dc.description.affiliationUnifespUniv Fed Sao Paulo UNIFESP, Dept Med, Div Nephol, Sao Paulo, Brazil
dc.description.sourceWeb of Science
dc.format.extent2148-2157
dc.identifierhttp://dx.doi.org/10.1111/ajt.13735
dc.identifier.citationAmerican Journal Of Transplantation. Hoboken, v. 16, n. 7, p. 2148-2157, 2016.
dc.identifier.doi10.1111/ajt.13735
dc.identifier.fileWOS000379727800023.pdf
dc.identifier.issn1600-6135
dc.identifier.urihttps://repositorio.unifesp.br/handle/11600/57662
dc.identifier.wosWOS:000379727800023
dc.language.isoeng
dc.publisherWiley-Blackwell
dc.relation.ispartofAmerican Journal Of Transplantation
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectclinical researchen
dc.subjectpracticeen
dc.subjectinfectious diseaseen
dc.subjectkidney transplantationen
dc.subjectnephrologyen
dc.subjectinfection and infectious agentsen
dc.subjectfungalen
dc.subjectepidemiologyen
dc.titleRisk Factors Associated With Early Invasive Pulmonary Aspergillosis in Kidney Transplant Recipients: Results From a Multinational Matched Case-Control Studyen
dc.typeinfo:eu-repo/semantics/article
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